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Skip to Search Results- 37Graduate and Postdoctoral Studies (GPS), Faculty of
- 37Graduate and Postdoctoral Studies (GPS), Faculty of /Theses and Dissertations
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Spring 2020
To ensure faithful cell division, entry into mitosis must be inhibited in cells with damage or under-replicated DNA. Wee1 and Myt1 are two partially redundant kinases that inhibit mitotic entry through the phosphorylation of the Cdk1/cyclin B complex. Cdk1 is an essential mitotic kinase that...
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Spring 2012
In Pulmonary Arterial Hypertension (PAH), pro-constrictive, pro-proliferative and anti-apoptotic diatheses converge to produce contraction and excessive proliferation of pulmonary artery smooth muscle cells (PASMC), a hallmark of PAH-vascular remodeling. The increased afterload causes right...
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Anti-Cancer Mechanism of Trastuzumab via Blocking Nuclear HER2 Function and Epigenetic Mechanism of Resistance
DownloadSpring 2020
HER2 receptor tyrosine kinase (encoded by ERBB2 gene) is overexpressed in approximately 25% of all breast cancer tumors (known as HER2-positive breast cancers). Overexpression of HER2 causes overactivation of downstream receptor tyrosine kinase pathways including PI3K/Akt and MAPK pathways and is...
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Association mapping of genes using whole genome polymorphism arrays: Identification of markers of breast cancer susceptibility in Alberta women
DownloadFall 2010
Chakravarthy Sridharan, Malinee
Breast cancer is a heterogeneous, polygenic disease and is influenced by genetic, environmental and life-style factors. Many single nucleotide polymorphisms (SNPs) associated with breast cancer risk have been identified in genome-wide association studies (GWASs) by several research groups for...
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Spring 2015
Autotaxin is a secreted enzyme that produces most of the extracellular lysophosphatidate from lysophosphatidylcholine, the most abundant phospholipid in plasma. Lysophosphatidate mediates many physiological and pathological processes by signaling through six G-protein-coupled receptors to promote...
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Spring 2012
This dissertation explores breast cancer experiences by predominately contemporary American women that are creative interventions into, and re-visions of, experiences in medical and therapeutic environs as well as culturally produced post-surgical bodies. During diagnoses, surgeries and...
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Spring 2017
This study is a qualitative secondary analysis of open-ended survey comments from a national survey of Canadian psychologists (n = 399) that extends the research of Jacobson, Hanson, and Zhou (2015). A case study research design is employed utilizing Consensual Qualitative Research (CQR) analytic...
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DDX17 (P72), a Sox2 binding partner, regulates Sox2 to sustain tumorigenic and stem-like properties in a phenotypically distinct subset of estrogen positive breast cancer cells
DownloadSpring 2016
Abstract: Sox2, an embryonic stem cell marker, is involved in the pathogenesis of breast cancer (BC). Sox2 expression is associated with a poor clinical outcome in BC patients. Based on the differential Sox2 transcriptional activity, we have identified the two phenotypically distinct cell...