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A Novel Comparative Analysis Approach to Personalize Chemotherapy Dose Calculation in Early Breast Cancer
DownloadFall 2018
Background Worldwide, body surface area [BSA] is used to calculate chemotherapy dose. The BSA formula was originally developed in 1916, derived from height and weight, with no consideration of other patient characteristics. Most chemotherapy agents have a narrow therapeutic index and are...
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An exploration into the relationship of body composition parameters and survival outcomes in patients with resectable colorectal cancer
DownloadFall 2018
Both tumor biology and host-specific factors play an important role in the prognosis of colorectal cancer. Body composition is an emerging patient-specific factor, which is currently being elucidated. Opportunistic analysis of pre-existing staging computed tomography scans can be used to quantify...
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Body Composition Assessment in Pediatric Obesity: Reliability, Validity, and Clinical Applications
DownloadFall 2020
Adipose tissue and skeletal muscle have unique metabolic roles. Despite body mass index for age and sex (BMI z-score) being historically widely used to evaluate and monitor health status in children with obesity, it does not depict adiposity and muscularity (or their changes) during growth or...