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- 3Wu, Jianping
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- 2Davidge, Sandra T.
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- 8Graduate and Postdoctoral Studies (GPS), Faculty of
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- 1Bell, Gordon (Physical Education and Recreation)
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NSAID Prodrugs with Improved Anti-inflammatory Activity and Low Ulcerogenicity: Wake Up Call to Pharmaceutical Companies and Health Authorities
DownloadSpring 2012
The objective of this work was to synthesize and evaluate the biological properties of a new series of nitric oxide-releasing non-steroidal anti-inflammatory drugs (NO-NSAIDs) possessing a tyrosol linker between the carboxylic acid present in classical NSAIDs and a NO-releasing group (PROLI/NO)...
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Remodeling of aorta extracellular matrix as a result of transient high oxygen exposure in newborn rats: implication for arterial rigidity and hypertension risk
Download2014-01-01
Huyard, Fanny, Yzydorczyk, Catherine, Castro, Michele M., Cloutier, Anik, Bertagnolli, Mariane, Sartelet, Hervé, Schulz, Richard, Nuyt, Anne Monique
Neonatal high-oxygen exposure leads to elevated blood pressure, microvascular rarefaction, vascular dysfunction and arterial (aorta) rigidity in adult rats. Whether structural changes are present in the matrix of aorta wall is unknown. Considering that elastin synthesis peaks in late fetal life...
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The Effect of Inhaled Nitric Oxide on Maximal Oxygen Consumption in High-fit and Untrained Individuals
DownloadFall 2019
Previous work suggests that endurance-trained athletes have superior pulmonary vasculature function as compared to untrained individuals, which may contribute to their greater maximal oxygen uptake (V̇O2max). Inhaled nitric oxide (iNO) improves pulmonary vascular compliance at rest in healthy...