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- 30Graduate and Postdoctoral Studies (GPS), Faculty of
- 30Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 1Agricultural, Food and Nutritional Science, Department of
- 1Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
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- 1Biochemistry, Department of/Journal Articles (Biochemistry)
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A Novel Comparative Analysis Approach to Personalize Chemotherapy Dose Calculation in Early Breast Cancer
DownloadFall 2018
Background Worldwide, body surface area [BSA] is used to calculate chemotherapy dose. The BSA formula was originally developed in 1916, derived from height and weight, with no consideration of other patient characteristics. Most chemotherapy agents have a narrow therapeutic index and are...
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Assessing the Feasibility of Learning Biomedical Phenotype Patterns Using High-Throughput Omics Profiles
DownloadSpring 2014
A decade after the completion of the human genome project, the rapid advancement of the high-throughput measurement technologies has made omics (genomics, epigenomics, transcriptomics, metabolomics) profiling feasible. The availability of such omics profiles has raised the hope for the...
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Binding, internalization, and transgene expression of an adenoviral vector retargeted to HER3/4
DownloadFall 2013
Adenoviruses (Ads) have been well studied for use in cancer gene therapy. However, low levels of the primary receptor, coxsackie-adenovirus receptor (CAR), in tumor cells has been shown to be a factor in low transgene expression. To increase Ad infection of breast cancer cells we constructed a...
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Decongestive Progressive Resistance Exercise with Advanced Compression for Breast Cancer Related Lymphedema Management (DREAM): A Pilot Randomized Control Trial
DownloadFall 2018
Introduction: More than one in five women who survive breast cancer will eventually develop lymphedema. Recent studies in breast cancer lymphedema management have demonstrated that resistance exercise can improve the survivors’ quality of life without exacerbating their lymphedema. However,...
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Deletion of F4L (ribonucleotide reductase) in Vaccinia Virus Produces a Selective Oncolytic Virus and Promotes Anti-tumor Immunity with Superior Safety in Bladder Cancer
DownloadFall 2017
Overall recurrence of non-muscle-invasive bladder cancer (NMIBC) can be as high as 80% within 5 years of initial treatment. High-grade NMIBC has the greatest risk of recurrence and treatment for these patients includes surgery followed by intravesical therapy with the immunotherapeutic agent...
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Delivery of STAT3 inhibitor cucurbitacins to tumor by polymeric nano-carriers : Implications in cancer chemo- and immunotherapy
DownloadFall 2009
Signal Transducer and Activator of Transcription 3 (STAT3), a common oncogenic mediator, is constitutively activated in many types of human cancers and plays a critical role in tumor growth and cancer immune evasion. The focus of this dissertation is the delivery of STAT3 inhibitor cucurbitacins...
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Development and Applications of Quantitative Mass Spectrometric Methods for Proteome and Protein Analysis
DownloadSpring 2013
Quantitative proteomics has been increasingly recognized as a key research topic in proteomics research, as it enumerates changes of proteins’ expression level in a bio-system. Quantitative proteomics provides an important way to discover biomarkers for disease diagnosis and prognosis, and also...
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Development of A Gadolinium-Based Nanotheranostics Platform for Irradiation Activatable MRI-Radiosensitization and Doxorubicin Release in Cancer Therapy
DownloadSpring 2022
The ultimate goal of this thesis research was to design, fabricate, and characterize an integrated nanotheranostics platform for activatable doxorubicin delivery and simultaneous MRI- radiosensitization for synergistic cancer therapy, targeting breast cancer treatment. As shown in the diagram,...
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Development of a Targeted Adenoviral Vector Expressing HSV-TK for use in Breast Cancer Gene Therapy and Analysis through Positron Emission Tomography
DownloadFall 2012
While adenoviral (Ad) vectors are the most commonly used gene delivery vector for human gene therapy, improvements must be made to increase Ad specificity to tumors if they are to be used for cancer gene therapy. Our goal is to target adenoviral vectors to breast cancer (BrCa) cells to induce...
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Development of novel compounds for the molecular imaging of hypoxia: 18F-labeled nitroimidazoles and hypoxia inducible factor 1 alpha (HIF-1a)-targeting compounds
DownloadSpring 2023
Imaging of hypoxia has been previously achieved using positron emission tomography (PET) with radiotracers such as [18F]fluoroazomycin arabinoside ([18F]FAZA) [1] or [18F]fluoromisonidazole ([18F]FMISO) [2]. These typical nitroimidazole containing compounds are reductively trapped in hypoxic...