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Skip to Search Results- 1Acevedo Morantes, Claudia Y
- 1Braithwaite, Shannon Lynn
- 1Ding, Ning
- 1Duque Velasquez, Juan C
- 1Eskandari-Sedighi, Ghazaleh
- 1Forbes, Keldi
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Fall 2016
Antemortem identification of Creutzfeldt-Jakob disease (CJD) patients is initially based upon clinical presentation of the disease. Symptoms are assessed in combination with results from cerebrospinal fluid (CSF) analysis, electroencephalography (EEG), magnetic resonance imaging (MRI), and...
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Spring 2022
Carotid atherosclerosis is responsible for 15-25% of the nearly 8 million first-ever ischemic strokes that occur each year worldwide. This proportion has remained constant over the past three decades, thus suggesting that some patients with carotid atherosclerosis currently receive suboptimal...
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Fall 2017
Prion disease, or transmissible spongiform encephalopathy (TSE), is a type of neurodegenerative disease for which there is no treatment and which is invariably fatal. Prion diseases are distinct in the field of biology and medicine, not only because they can be sporadic, infectious, or inherited,...
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Cervid Prion Protein Polymorphisms Modulate the Diversity of Chronic Wasting Disease Prion Strains
DownloadSpring 2017
Chronic wasting disease (CWD) is a contagious prion disease spreading and emerging in wild and captive Cervidae species worldwide. Prion diseases are fatal neurodegenerative disorders occurring in various mammalian species including deer, elk, sheep, cattle and humans. Central to prion...
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Fall 2019
Human prion diseases present as sporadic, familial, infectious, or iatrogenic forms. They include diseases such as Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker syndrome (GSS), and Fatal Familial Insomnia (FFI). The wide range of phenotypic variation in human prion diseases is...
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Characterizing patterns of tissue tropism and environmental reservoirs of PrPCWD in infected cervids
DownloadFall 2013
Chronic wasting disease (CWD) is a fatal prion disease affecting cervids. Believed to be transmitted horizontally, the factors affecting CWD contagion are unknown, but bodily fluids or excretions have been implicated as possible routes of transmission. Protein misfolding cyclic amplification...
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Fall 2012
Provided that infectious prions (PrPTSE) are inactivated, composting of specified risk material (SRM) may be a viable alternative to rendering and land filling. The overall objective of this research was to utilize laboratory-scale composters to assess the degradation of SRM and PrPTSE during...
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Evaluating the Role of Bacterial Lipopolysaccharide on Etiology and Pathogenesis of Transmissible Spongiform Encephalopathies
DownloadFall 2014
Transmissible spongiform encephalopathies (TSEs) or otherwise known as prion diseases are a class of fatal neurodegenerative diseases related to irreversible brain damage. Presently, there is no effective treatment or preventive strategy for this disease because the etiology and biological...
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Fall 2021
Background Human Immunodeficiency Virus (HIV) is a major cause of mortality and morbidity globally. Vertical transmission is the primary mode of HIV acquisition among infants. Although successful interventions have reduced vertical transmission to less than <2.9% in low-to-middle income countries...
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Identification of biomarkers associated with the onset and progression of ketosis in transition dairy cows
DownloadFall 2016
Ketosis is a common metabolic disorder of transition dairy cows during the early lactation period. Cows with ketosis have lower milk yield and reproductive performance, greater risk of other periparturient diseases, and higher culling rate. Although ketosis has been extensively studied, not many...