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Skip to Search Results- 1Aderibigbe, Ayodeji O.
- 1Akbari, Ali
- 1Akgun, Burcin
- 1Al-Momany, Abass M T
- 1Araya, Luam Ellen
- 1Bak, Jessi J.
- 8Department of Biochemistry
- 6Department of Chemistry
- 4Department of Electrical and Computer Engineering
- 3Department of Agricultural, Food, and Nutritional Science
- 2Department of Medicine
- 2Department of Physiology
- 2Kurgan, Lukasz (Electrical and Computer Engineering)
- 2Overduin, Michael (Biochemistry)
- 1Ball, Ronald O. (Department of Agricultural, Food and Nutritional Science)
- 1Ballermann, Barbara (Medicine)
- 1Barbara Ballermann (Physiology, adjunct - Nephrology Dept. of Medicine)
- 1Boekhoven, Job (Chemistry, Technical University of Munich)
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A novel mouse model of acute antibody-mediated transplant rejection shows simultaneous complement activating and anti-inflammatory effects of donor specific IgG antibodies
DownloadFall 2013
We developed a small animal model of pure antibody-mediated rejection (ABMR) by utilizing fully major histocompatibility complex (MHC) mismatched kidney allografts in mice. By examining resultant ABMR pathology, we show that terminal complement products C5a and C5b-9 are crucial in establishing...
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Spring 2015
Background: Heart transplant is life-saving for children with end-stage congenital heart disease or acquired heart failure. Critical illness following transplantation can include acute kidney injury (AKI). There is little data on the epidemiology of, risk factors for, or impact on outcomes of...
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An examination of linking and blocking procedures for use in deflection cantilever array-based protein detection
DownloadFall 2011
In this project common linking and blocking procedures were examined for use in multiplexed deflection cantilever array-based detection of proteins. A human interferon gamma (INF-γ) enzyme-linked immunosorbent assay (ELISA) kit was used to evaluate the effectiveness of the linking and blocking...
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Fall 2014
An organoarsenic compound, 3-nitro-4-hydroxyphenyl arsenic acid (also known as Roxarsone), has been used as a feed additive. Roxarsone was approved by the Food and Drug Administration (FDA) to control diseases in poultry, and to improve weight gain, feed efficiency, and meat pigmentation....
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Spring 2018
The development of rapid and bioorthogonal chemical reactions has expanded greatly the utility of bioconjugation chemistry in the service of site-selective protein labeling, even allowing molecular imaging in live cells or animals. âClickâ chemistry is particularly desirable due to its fast...
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Spring 2021
Splicing is an essential step in the post-transcriptional modification of pre-mRNAs in eukaryotes. This process is catalyzed by the spliceosome, a multi-megadalton nuclear protein-RNA enzyme which excises non-coding sequence from RNA transcripts prior to translation. Deficient or improper...
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Spring 2015
The kidneys regulate total body fluid volume, acid-base status, and electrolyte composition through the filtration of large amounts of plasma by glomerular capillaries, followed by selective reabsorption of solutes and water by renal tubules. To sustain filtration, the hydraulic pressure within...
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Fall 2016
α-Synuclein has been implicated in the progression of Parkinson’s disease, a neurodegenerative disorder that affects millions of people worldwide. This work reports on the structural propensity and druggability of this protein using a combination of Monte Carlo, Molecular Dynamics, and Virtual...
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Computational support systems for prediction and characterization of protein crystallization outcomes
DownloadFall 2013
Analysis of protein structures may reveal their function, regulation and interactions. Almost 90% of the known protein structures were solved using X-ray crystallography; however, many more structures remain unsolved. Protein Structure Initiative (PSI) project was created to speed up structure...