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Characterization of the Protein Interaction Networks of Necdin and MAGEL2: Insight into How Loss of These Proteins Contributes to Neurodevelopmental Disease
DownloadFall 2020
Prader-Willi Syndrome (PWS) is a neurocognitive developmental disorder that is caused by the deletion or inactivation of paternal genes in the chromosomal region 15q11-q13. The MAGEL2 and NDN (encoding necdin) genes are within the deleted region. Individuals with PWS tend to be obese due to...
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Fall 2020
The Golgi complex resides at the center of the cellular trafficking pathway, where it functions in the modification, sorting, and trafficking of over one third of human proteins to their correct cellular destination. Initiation of vesicle formation at the Golgi requires activation of small...