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Fall 2014
Carbohydrate–protein interactions play key roles in a range of biological processes. Noticeable advancements have been made in understanding the features associated with the recognition of pyranosides (six-membered ring sugars) by proteins. In contrast, similar detailed studies about the...
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Molecular Mechanisms Underlying the Enhancement of Cardiac Contraction by Modifications of Troponin
DownloadFall 2015
A fine balance between contraction and relaxation is crucial for the heart to function properly. But often the heart cannot contract with enough force to meet the demands of the body. This condition, called systolic heart failure, is the leading cause of death in the modern society. A common...
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Structure and proteolytic digestion of the intrinsically disordered C-terminal tail of cardiac troponin I
DownloadSpring 2019
Intrinsically disordered regions (IDRs) are protein sequences that do not acquire a fixed 3-D configuration under physiologic conditions. Their solvent-exposed nature makes them susceptible to post-translational modifications like proteolysis, which makes them vital for cellular regulation....