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Skip to Search Results- 4Finlay, B. Brett
- 4Gänzle, Michael G.
- 4Willing, Benjamin P.
- 2Antunes, L. Caetano M.
- 2Croxen, Matthew A.
- 2Dieleman, Levinus A.
- 16Graduate and Postdoctoral Studies (GPS), Faculty of
- 16Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 11Agricultural, Food and Nutritional Science, Department of
- 11Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 2Agricultural, Life, and Environmental Sciences, Faculty of
- 2Agricultural, Life, and Environmental Sciences, Faculty of/Journal Articles (Agricultural, Life, & Environmental Sciences)
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Spring 2017
Ruminants have the capacity to utilize fibrous plant materials as substrates to provide energy for maintenance and growth. However, digestion of poor quality forage is incomplete in ruminants and varies among individual animals. Consequently, two studies were conducted in an attempt to elucidate...
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Profiling the Bacterial and Fungal Gut Microbiome of Children with and without Prader-Willi Syndrome (PWS)
DownloadFall 2020
Obesity is a complex multifactorial disease that has a large array of direct (e.g. altered metabolic and inflammatory profile) and indirect (e.g. mental health concerns etc.) consequences on health and is associated with increased morbidity and mortality. Prader-Willi Syndrome (PWS) is the most...
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Regulation of digestive tract and progenitor cell homeostasis by intestinal bacteria in Drosophila melanogaster
DownloadFall 2020
The digestive tract facilitates nutrient uptake in the presence of a heterogenous cohort of symbiotic microbes. These microbes along with their collective genetic material form the intestinal microbiome and contribute to animal phenotypes. Similar to mammals, the microbiome of insects forms a...
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Small intestine early innate immunity response during intestinal colonization by Escherichia coli depends on its extra-intestinal virulence status
Download2016
Denamur, Erick, Tourret, Jérôme, Dion, Sara, Willing, Benjamin P., Wachtel, Sarah, Finlay, B. Brett, Dufour, Nicolas, Croxen, Matthew A.
Uropathogenic Escherichia coli (UPEC) strains live as commensals in the digestive tract of the host, but they can also initiate urinary tract infections. The aim of this work was to determine how a host detects the presence of a new UPEC strain in the digestive tract. Mice were orally challenged...
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The intestinal microbiota plays a role in Salmonella-induced colitis independent of pathogen colonization
Download2011
Antunes, L. Caetano M., Gill, Navkiran, Russell, Shannon L., Finlay, B. Brett, Ferreira, Rosana B., Croxen, Matthew A., Willing, Benjamin P.
The intestinal microbiota is composed of hundreds of species of bacteria, fungi and protozoa and is critical for numerous biological processes, such as nutrient acquisition, vitamin production, and colonization resistance against bacterial pathogens. We studied the role of the intestinal...
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Spring 2022
BackgroundEvidence is emerging that the gut microbiome is an important contributor to the weight and metabolic effects of bariatric surgery. However, the microbial and intestinal physiological changes that occur with bariatric surgery are poorly understood. Developing this understanding...
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Spring 2015
Ileocolic resection is frequently performed for Crohn's disease; however, disease commonly recurs early in the neo-terminal ileum. The aim of this thesis was to investigate the microbial and immunologic factors inherent to ileocecal resection as they pertain to post-operative recurrence of...
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The role of intestinal microbiota in development of irinotecan toxicity and in toxicity reduction through dietary fibres in rats
Download2014
Baracos, Vickie, Dieleman, Levinus, Farhangfar, Arazm, Lin, Xiaoxi B., Gänzle, Michael G., Sawyer, Michael B., Valcheva, Rosica, Schieber, Andreas
CPT-11 is a drug used as chemotherapy for colorectal cancer. CPT-11 causes toxic side-effects in patients. CPT-11 toxicity has been attributed to the activity of intestinal microbiota, however, intestinal microbiota may also have protective effects in CP!-11 chemotherapy. This study aimed to...
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Understanding the role of Clostridioides difficile and Vitamin D supplementation in shaping the gut microbiome of Canadian infants
DownloadSpring 2019
Introduction: The gut microbiome is shaped during infancy and has an important role in the development of both the immune and metabolic systems. Many early life exposures and events contribute to the composition of this complex intestinal environment, notably early infant diet and breastfeeding....