Search
Skip to Search Results- 2Veldhoen, Richard
- 1Alsaleh, Nasser B
- 1Githaka, John M
- 1Gänzle, Michael G.
- 1Harbison, Adrian Mark.
- 1Herrera, Maria S
- 19Graduate and Postdoctoral Studies (GPS), Faculty of
- 19Graduate and Postdoctoral Studies (GPS), Faculty of /Theses and Dissertations
- 1Agricultural, Food and Nutritional Science, Department of
- 1Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
-
Spring 2016
There is ample evidence that autophagy is affected in Alzheimer’s disease (AD) but the causes, the nature of the dysfunction and the mechanisms of autophagy impairment are unclear. Autophagy depends on vesicular trafficking and membrane fusion, events that rely on several protein complexes and...
-
Fall 2019
Alzheimer’s disease (AD) is characterized by the accumulation of amyloid beta (Aβ) peptide. It has been proposed that AD pathology is transmissible by a “prion-like” mechanism through extracellular vesicles (EVs) that contain Aβ. In this context, EVs describe both microvesicles and exosomes,...
-
Fall 2009
β-Glucan is a soluble fibre shown to help regulate blood sugar and lower cholesterol. Incorporation into food, particularly bread, may affect β-glucan’s physicochemical properties and health benefits. The journey of β-glucan through the mixing, fermenting, baking, and storage of bread was...
-
Fall 2017
Prion disease, or transmissible spongiform encephalopathy (TSE), is a type of neurodegenerative disease for which there is no treatment and which is invariably fatal. Prion diseases are distinct in the field of biology and medicine, not only because they can be sporadic, infectious, or inherited,...
-
Characterization and Functional Beverage Development using Coenzyme Q10-Impregnated Beta-glucan
DownloadSpring 2017
Pressurized gas-expanded liquid (PGX) technology is a supercritical fluid technique used for producing micro/nano-particles, agglomerates and fibers from an aqueous solution of a high molecular weight biopolymer, which can also be employed for encapsulation or impregnation. PGX-processed...
-
Fall 2014
Fungal pathogens are recognized by Dectin-1, a pattern recognition receptor expressed on mammalian innate immune cells. Dectin-1 detects β-glucans, which are polymers of glucose that are a main component of the fungal cell wall. While purified, soluble β-glucans have been used in the clinic as...
-
Fall 2013
West Nile virus (WNV) is a neurotropic, blood-borne flavivirus that can cause serious neurological disease in humans and animals. While significant progress has been made in identifying virus-encoded pathogenic determinants, very little is known regarding how these viral proteins interact with...
-
Inactivation of Magel2 in a mouse model of Prader-Willi Syndrome alters autophagy in the hypothalamus and impairs muscle function
DownloadFall 2016
Prader-Willi Syndrome (PWS) is a neurodevelopmental disorder causing severe neonatal hypotonia that persists until adulthood, reduced muscle mass, and hyperphagia leading to childhood-onset obesity. PWS is caused by inactivation of several genes located on chromosome 15q11-q13, including MAGEL2....
-
Fall 2018
Huntington’s disease (HD) is a monogenic neurodegenerative disorder characterized by progressive choreic movements, dystonia, motor incoordination, cognitive decline and behavioural changes. HD is caused by an abnormal increase in the number of CAG repeats in the exon 1 of the huntingtin (HTT)...