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Fall 2019
The processes of assembly and disassembly of colloids has rapidly grown in interest over the decades. Assembly and disassembly are able to respond to the changes in conditions, which makes them important in sensing and stimuli-reponsive processes. There are two applications based on assembly and...
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Modular Design and Directed Evolution for the Development of Genetically Encodable Fluorescent Sensors
DownloadSpring 2019
The development of genetically encodable sensors for optical imaging has revolutionized the way researchers investigate cellular phenomena. Illuminating the molecular dynamics of the cell has become nearly routine with countless improvements in sensor design and directed evolution efforts to...
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Fall 2014
The assembly of nanoparticle building blocks into more complex nanostructures has important applications in analytical chemistry, materials science, medical science, optics, and electronics. Due to its exquisite specificity and programmable nature, DNA has emerged as a very promising biomolecule...
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The Influence of Specific Ions and System Architecture on the Recognition and Reactivity of Two Charged Materials: DNA-Modified Gold Nanoparticle Aggregates and Planar Silica
DownloadFall 2014
DNA functionalized gold nanoparticles (GNP–DNA) offer simple colorimetric nucleic acid sensing with high selectivity and sensitivity. Consequently, they are promising in genetic profiling, disease diagnostics, and forensic applications. In the presence of a target nucleic acid, GNP–DNA forms...
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Fall 2014
Developing a simple, general, and isothermal self-replicating system is one of the key requirements for a simplified detection platform for nucleic acid sequences specific to a disease causing microrganism. One of the challenges in achieving nucleic-acid templated isothermal amplification is that...