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Spring 2018
Head and neck squamous cell carcinoma (HNSCC) is the 6th most prevalent cancer worldwide with rates of human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) dramatically increasing. The overexpression of enhancer of zeste homolog 2 (EZH2), a histone methyltransferase...
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The Role of Cyclosporine Treatment in Cardioprotection during Resuscitation of Asphyxiated Newborn Piglets
DownloadFall 2012
Asphyxiated neonates often have myocardial depression which is a significant cause of morbidity and mortality. Cardioprotective effects of cyclosporine have been observed in adult animal models and human trials with myocardial infarction. However, the cardioprotective effect of cyclosporine in...
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Fall 2013
Asphyxia is a significant cause of newborn morbidity and mortality. Multiorgan injury and dysfunction is a common finding, mediated in part through an increase in matrix metalloproteinase (MMP) activity. We hypothesized administration of doxycycline, a known MMP inhibitor, would improve systemic...
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Fall 2013
Cardiovascular dysfunction in asphyxiated neonates leads to significant morbidity and mortality and the hemodynamic support is limited to the use of catecholamines. In a pilot study, we showed that low-dose vasopressin improved myocardial tissue lactate levels, suggesting decreased anaerobic...