Search
Skip to Search Results- 17Electrophysiology
- 9Arachidonic acid
- 3Cardiac hypertrophy
- 3Docosahexaenoic acid
- 2Anesthesia
- 2Caffeine
- 1Abdul Rahman, Siti Aishah
- 1Aghazadeh Habashi, Ali
- 1Al Lawati, Hanan M
- 1Alles, Sascha R
- 1Alsaad,Abdulaziz M
- 1Beaulieu, Michael J.
- 5Centre for Neuroscience
- 5Faculty of Pharmacy and Pharmaceutical Sciences
- 4Department of Physiology
- 3Department of Pharmacology
- 3Neuroscience
- 2Department of Agricultural, Food, and Nutritional Science
- 2Tse, Amy (Centre for Neuroscience and Department of Pharmacology)
- 1Ballanyi, Klaus (Physiology Department, University of Alberta)
- 1Brocks, Dion (Pharmacy and Pharmaceutical Sciences)
- 1Chen, Xing-Zhen (Physiology)
- 1Clayton T. Dickson (Psychology, Physiology, Anesthesia and Pain Medicine, Neuroscience and Mental Health Institute)
- 1Colmers, William F. (Pharmacology)
-
Role of CYP-mediated Arachidonic Acid Metabolites in Development of Cardiac Hypertrophy and Chronic Doxorubicin-induced Cardiotoxicity
DownloadSpring 2013
Drug-induced cardiotoxicity is classified as a predisposing factor leading to cardiac hypertrophy and heart failure. Of importance, doxorubicin (DOX, adriamycin) is considered as an effective anticancer agent whose major limiting side effect is cardiotoxicity. Of importance, several studies...
-
Fall 2023
Sleep is a vital neurobiological process, yet despite its fundamental significance, delineating the endogenous neural pathways involved has been slow to progress due to a lack of diverse sleep models. Anesthesia, which has direct behavioural parallels to natural sleep, and which is often linked...
-
The effect of long-term interleukin-1 beta exposure on sensory neuron electrical membrane properties: implications for neuropathic pain
DownloadSpring 2011
The effect of interleukin-1 beta (IL-1β) on the electrical properties of sensory neurons was assessed at comparable levels and exposure times to those found in animal models of neuropathic pain. Experiments involved whole cell current- or voltage-clamp recordings from rat dorsal root ganglion...
-
Fall 2015
Nucleosides are essential for RNA and DNA synthesis. They also play a central role in other cellular metabolic pathways, and modulate a diverse array of physiological processes, including renal and cardiovascular function and neurotransmission. Due to their hydrophilic nature, specialized...
-
The role of cytochrome P450 derived arachidonic acid metabolites against Angiotensin II-induced cardiac hypertrophy in Sprague Dawley rats and the RL-14 cell line
DownloadFall 2015
Several cytochrome P450 (CYP) enzymes and their arachidonic acid (AA) metabolites play essential roles in the maintenance of cardiovascular health, and their alteration gives rise to a number of cardiovascular diseases, including cardiac hypertrophy and heart failure. Recent data demonstrated...
-
Using EEG to examine inhibitory abilities in children: The effects of time pressure, physical activity, and emotion
DownloadFall 2018
The ability to inhibit inappropriate actions and irrelevant information is crucial for adaptive functioning. Inhibitory skills emerge early in life, with significant growth occurring during the period of early and middle childhood. The objective of this dissertation was to utilize...