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Skip to Search Results- 61Graduate and Postdoctoral Studies (GPS), Faculty of
- 61Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 38Biological Sciences, Department of
- 38Biological Sciences, Department of/Journal Articles (Biological Sciences)
- 7Philosophy, Department of
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- 63Article (Published)
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Fall 2014
Developing a simple, general, and isothermal self-replicating system is one of the key requirements for a simplified detection platform for nucleic acid sequences specific to a disease causing microrganism. One of the challenges in achieving nucleic-acid templated isothermal amplification is that...
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Understanding the evolution of the membrane trafficking system in diverse eukaryotes through comparative genomics and transcriptomics
DownloadSpring 2018
Single-celled organisms represent the majority of eukaryotic diversity. Recent advances in sequencing technologies have been critical for understanding the evolutionary biology and cell biology of microbial eukaryotes. Comparative genomic analyses have shown that many genes that underlie...
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Unequal recombination and evolution of the mating-type (MAT) loci in the pathogenic fungus Grosmannia clavigera and relatives. G3: Genes, Genomes, Genetics
Download2013-01-01
Hamelin, Richard C., Tsui, Clement K.M., Bohlmann, Jörg, DiGuistini, Scott, Dhillon, Braham, Feau, Nicolas, Wang, Ye
Sexual reproduction in fungi is regulated by the mating-type (MAT) locus where recombination is suppressed. We investigated the evolution of MAT loci in eight fungal species belonging to Grosmannia and Ophiostoma (Sordariomycetes, Ascomycota) that include conifer pathogens and beetle symbionts....
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Using Biomolecular Recognition to Selectively Self-Assemble Microscale Components onto Patterned Substrates
DownloadSpring 2015
Modern nanofabrication technology in the 21st century has continued year after year to push the boundaries of what is possible at the nanoscale. With the advent of molecular electronics, single electron devices, nanoelectromechanical systems (NEMS), and other nanotechnologies, the near future...
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Fall 2014
Smallpox was eradicated using vaccinia viruses (VACV) as vaccines, including Dryvax, a calf-lymph vaccine derived from the New York City Board of Health (NYCBH) strain, and TianTan, a chicken egg cultured vaccine used exclusively in China. To take advantage of the next generation sequencing...
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Vaccinia virus DNA polymerase and ribonucleotide reductase: their role in replication, recombination and drug resistance
DownloadSpring 2010
Despite the eradication of smallpox, poxviruses continue to cause human disease around the world. At the core of poxvirus replication is the efficient and accurate synthesis and repair of the viral genome. The viral DNA polymerase is critical for these processes. Acyclic nucleoside phosphonate...
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Fall 2021
Poxviruses encode many genes that are orthologs of cellular genes. These orthologs serve many functions, but those that are of most interest are ones that have evolved further and now serve an immune-evasion function. Such genes were likely first acquired by poxviruses through some form of...