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Skip to Search Results- 1Agustin, Roman, V
- 1Anderson-Baron, Matthew N
- 1Chang, Jinlan
- 1Eitzen, Gary A.
- 1Espinosa Gonzalez, Maria I
- 1Greer, Michael S
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A comprehensive assessment of peroxisome biology: ER-dependent peroxisome proliferation control, evolution of organelle inheritance in yeast and a Drosophila model system of Zellweger syndrome
DownloadFall 2013
The modern eukaryotic cell is a meshwork of encapsulating membranes that compartmentalize many distinct biochemical processes. It is complex. This complexity facilitates the many unique and diverse processes that aid the eukaryote in its growth, division and adaptation to its environment. A...
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A role for the nuclear pore complex protein Nup170p in defining chromatin structure and regulating gene expression
DownloadSpring 2012
The spatial organization of chromosomal loci within the nucleus can have a significant influence on transcriptional activity. Transcriptionally active genes are generally positioned within the nuclear interior. By contrast, the positioning of genes at the nuclear periphery is often correlated...
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An ancestral role in de novo peroxisome assembly is retained by the divisional peroxin Pex11 in the yeast Yarrowia lipolytica
DownloadFall 2014
This thesis is on peroxisome evolution and reports my findings with regard to two major aspects of this process. First, I investigated the evolution of a peroxisomal protein family for which large expansions had been noted in diverse eukaryotes from a comparative genomic perspective and combined...
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Fall 2017
Flaviviruses are important human pathogens that have an enormous impact on global health. Examples that have been studied in my research include dengue virus (DENV), West Nile virus (WNV) and most recently, Zika virus (ZIKV). Currently, there are very few vaccines against or therapeutic...
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Spring 2014
Metabolomics involves the high throughput characterization of small molecules or metabolites in cells, tissues and organisms. To interpret, store and exchange metabolomic data it is necessary to have comprehensive, electronically accessible databases that can be used to handle both the...
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Development of technological alternatives to produce renewable fuels from oleaginous microorganisms
DownloadFall 2014
Microbial lipids are a promising feedstock for the production of renewable fuels. However, use of microbial lipids has been hindered due to challenges in the cultivating and processing of microbes. Thus, innovative technologies are required to enhance the feasibility of integrating oleaginous...
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Engineering Enhanced Performance in Plant Diacylglycerol Acyltransferase and Long-Chain Acyl-CoA Synthetase
DownloadSpring 2018
Triacylglycerol (TAG) is the major storage lipid in higher plants and has great nutritional and industrial value. Plant storage lipid biosynthesis involves different subcellular compartments and a complex network of enzymes and proteins. Among them, endoplasmic reticulum (ER)-bound diacylglycerol...