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- 2Envelope stress
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- 1Cpx stress response
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Characterization of novel envelope proteins and their relationship with the Cpx response and stress resistance in Escherichia coli
DownloadFall 2022
Stress is a major factor every organism needs to mitigate to survive. Environmental factors such as oxygen content, temperature, and alkalinity can all induce stress and prevent life from progressing. For Escherichia coli and other members of the mammalian gastrointestinal tract they need to...
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The role of cysteine and the Cpx envelope stress response in alleviating zinc induced stress in Escherichia coli
DownloadFall 2018
Circumscribing the interior of Gram negative bacteria are two sets of layers: an inner and outer membrane. The periplasm and murein occupy the space between these membranes and acts as a site for protein folding and degradation. The bacterial envelope, as a whole, plays an essential role in the...
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Fall 2017
Gram-negative bacteria are separated from the environment by a multilayered structure known as the envelope, which is comprised of the outer membrane, the inner membrane and the aqueous periplasmic space that lies between the two membranes. Biogenesis of the envelope is a complex process that...
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Molecular Mechanisms Used by Auxiliary Regulator NlpE to Signal the Cpx Envelope Stress Response in Escherichia coli
DownloadSpring 2017
The Cpx two-component system senses and mediates adaptation to envelope stresses in Escherichia coli. NlpE is an outer membrane lipoprotein that senses surface adhesion and signals the Cpx pathway. This work focused on investigating the molecular mechanisms used by NlpE to signal the Cpx pathway...
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The Cpx envelope stress response of Escherichia coli regulates and is regulated by the small RNA RprA
DownloadFall 2015
When bacteria sense changes in their environment, they adapt by altering the expression of their genes in such a way that accommodates the change. To do this, bacterial cells can modulate the activity of their genes at either the level of transcription, or at the post-transcriptional level....