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Skip to Search Results- 1Adam, Ibrahim S. Y.
- 1Akinwumi, Segun M
- 1Alford, Spencer Caleb
- 1Anbukarasu, Preetam
- 1Assempour, Nazanin
- 1Belal, Ahmed S. F.
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Spring 2015
Fluorescent proteins (FP) and FP-based biosensors have become essential tools for cell biology and neuroscience research. This thesis describes efforts to engineer new FPs with red emission and novel genetically encoded biosensors based on red FPs. Directed evolution and semi-rational design are...
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Fall 2022
Affinity maturation is the process to improve antibody affinity for an antigen during an adaptive immune response; it is mediated by the immunoglobulin mutator enzyme activation-induced cytidine deaminase (AID). This process is crucial to produce high-affinity memory B-cells and plasma cells. In...
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Fall 2015
The expansion of the fluorescent protein (FP) colour palette through discovery of more species possessing FPs and by subjecting them to intensive protein engineering efforts has greatly aided the effectiveness of FP-based biosensor designs. Currently, the main FP-based methods for detecting...
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Spring 2013
Research was undertaken into the organic semiconductors tris(8- hydroxyquinoline)aluminum (Alq3) as well as bis(8-hydroxyquinoline)zinc (Znq2) to the effect of improving achievable morphological control using an inexpensive evaporation based solution synthesis method. By varying experimental...
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Fall 2022
Background: Although pediatric heart transplantation is a life-saving and effective therapy for children with cardiac disease, barriers remain due to a lack of available organs as well as transplant failure due to rejection. This dissertation aimed to increase knowledge related to immune risk...
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Fall 2018
Tuberculosis (TB) is a chronic pulmonary disease caused by Mycobacterium tuberculosis (Mtb). Mtb spreads by aerosol and infects through the airways. Mtb is phagocytosed by macrophages in the lung, and is able to replicate inside these cells. The initial infection of Mtb with macrophage results in...
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Integration of Nanomechanical Resonators in Microfluidic Systems for Specific Protein Detection
DownloadFall 2009
Nanomechanical resonators offer a pathway towards highly sensitive and label-free detection of biomolecules by transducing the mass of bound analytes into resonant frequency shifts. Zeptogram level and even single cell detections have been successfully achieved by others. However, these...
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Fall 2023
The calving transition is a challenging period for dairy cows characterized by negative energy balance, metabolic dysfunction, and inflammation, each of which may compromise milk production. Despite extensive research in this area, much is still unknown on how to best manage this period. The...
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Investigation of the immunological cross-reactivity between Plasmodium vivax Duffy Binding Protein and Plasmodium falciparum VAR2CSA for vaccine development
DownloadFall 2021
Worldwide, an estimated 30 million pregnancies are at risk of malaria infection each year. In pregnancy, Plasmodium falciparum parasites express a protein called VAR2CSA that mediates adherence of infected red blood cells (iRBCs) to chondroitin sulfate A (CSA) in the placenta. VAR2CSA antibodies...
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Fall 2010
Human T-lymphotropic virus type I (HTLV-I) is a persistent human retrovirus characterized by life-long infection and risk of developing HAM/TSP, a progressive neurological and inflammatory disease. Despite extensive studies of HTLV-I, a complete understanding of the viral dynamics has been...