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Spring 2011
Angiotensin II signals cardiovascular disease through metalloproteinases including MMP-2, MMP-7 and ADAM-17/TACE. We hypothesized that these metalloproteinases regulate each other at the transcriptional level. Further, MMP-2, being a major gelatinase in cardiac and vascular tissue, could mediate...
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Role of Disintegrin and Metalloproteinase 17 (ADAM17) in Hypertension and Thoracic Aortic Aneurysm
DownloadFall 2018
Hypertension is a major risk factor for cardiovascular complications such as stroke, myocardial infarction, heart failure, and renal failure, and therefore is an enormous healthcare burden worldwide. The renin-angiotensin system (RAS) is an essential regulator of blood pressure homeostasis, and...