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Skip to Search Results- 1Athanassakis-Vassiliadis, Irene
- 1Berke, Sheldon S
- 1Chahal, Manik
- 1Chordiya, Pritam M
- 1Davey, Ashley
- 1Farhan, Maikel AA
- 3Department of Medicine
- 3Department of Oncology
- 2Department of Agricultural, Food, and Nutritional Science
- 2Department of Civil and Environmental Engineering
- 2Department of Medical Sciences
- 1Department of Biochemistry
- 1Abdulkarim, Bassam (Oncology)
- 1Adeeb, Samer (Civil and Environmental Engineering)
- 1Allan Murray (Medicine)
- 1Ambrose, Divakar (Department of Agricultural, Food and Nutritional Science)
- 1Bell, Rhonda (Department of Agricultural, Food, and Nutritional Science)
- 1Carroll, Linda (Supervisor - School of Public Health, University of Alberta)
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Fall 2016
Thrombotic microangiopathy (TMA) is a broad term for a range of diseases that usually manifest with rapid failure of the affected organ. Although different in etiology, these diseases share a common pattern of injury originating in the vascular endothelium. In turn, the injured vasculature...
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Manipulation of the Angiogenic Balance by Pharmacological Inhibition of Platelet PKC Signalling
DownloadFall 2012
Blood platelets mediate wound healing by preventing bleeding and by supporting growth of new blood vessels. Blood vessel growth is supported in part by growth factors released from platelet α-granules. Both platelet aggregation and α-granule release are mediated by intracellular signaling...
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Fall 2013
The placenta is an essential transitory fetal organ responsible for the key processes of nutrient, oxygen, and waste transfer between the mother and the fetus throughout gestation. Placental size is, importantly, known to correlate to fetal weight, and the malfunction and malformation of the...
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Novel Insights into the Role of O6-Methylguanine-DNA Methyltransferase in Glioblastoma Angiogenesis, Invasion, and Proliferation
DownloadFall 2012
Glioblastoma multiforme (GBM) is characterized by aberrant angiogenesis, rapid proliferation, and widespread invasion through the brain parenchyma. Thus, the prognosis for these tumors remains extremely poor despite aggressive multimodal treatment including chemotherapy with the alkylating agent...
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Plasma Membrane Organization and Endocytosis of CD36 in Human Microvascular Endothelial Cells
DownloadSpring 2016
The plasma membrane is a dynamic lipid bilayer that surrounds the cell, embedded with different plasma membrane proteins, aiding communication between the inside and outside of the cells. Its functions are achieved through an intricate organization of lipid-lipid, lipid-protein and...
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Fall 2015
Poisoning injuries constitute a significant health problem worldwide. Suicide is one of the leading causes of deaths and poisoning is the most common method utilized for the same. The objectives of this program of research were: 1) to systematically review existing studies analyzing the...
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Prediction of Load-Sharing Mechanisms and Patterns of Human Cervical Spine Injuries Due to High-Velocity Impact Using Finite Element Method
DownloadFall 2013
The purpose of the current study was to investigate the loading rate dependency, load-sharing and injury mechanisms of the C2-C3 cervical spine unit. A ligamentous bio-realistic finite element model was constructed considering comprehensive geometrical representation at tissue level components...
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Sensory Nerve Injuries: Advances in Diagnosis and Novel Therapy to Enhance Sensory Recovery in Humans
DownloadFall 2013
The unique difference between central and peripheral nervous systems is that regeneration actually occurs in the periphery. However, the functional recovery after surgical repair is highly variable and return to pre-injury state despite surgical advances is rare. When specifically looking at...
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Spring 2011
Human Cytomegalovirus (HCMV) is the most common cause of congenital infection in newborns. One mechanism for this virus to reach the fetus is to cross the placenta through the syncytiotrophoblast layer. Accumulation and protection of pathogens in the syncytiotrophoblast could affect the systemic...