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Skip to Search Results- 1Berke, Sheldon S
- 1Chahal, Manik
- 1Corrigan, Jennifer
- 1Farhan, Maikel AA
- 1Fung, Rachel D
- 1Githaka, John M
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Bilateral Uterine Artery Ligation in Rats cultivates Long Term Neurological Deficits reminiscent of Human Cerebral Palsy: A model for Therapeutic Intervention.
DownloadFall 2015
Introduction Cerebral Palsy (CP) is a ubiquitous term used to describe a group of permanent, non-progressive disorders of movement, posture, and behaviour. Despite countless advances in neonatal medicine, the incidence of CP has remained constant in term infants over the last three decades. More...
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Cardiovascular Effects of Aerobic Exercise Training in Hypoxic-induced Intrauterine Growth Restriction
DownloadFall 2017
Fetal hypoxia is one of the most common consequences of complicated pregnancies worldwide. It has been demonstrated that prenatal hypoxia leads to intrauterine growth restriction (IUGR). Being born growth restricted is associated with a decrease in cardiomyocyte proliferation, an increased...
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Combination Radiation Therapy and Oncolytic Vaccinia Virus Therapy in Preclinical Models of Glioma
DownloadSpring 2017
Gliomas are the most common primary malignant brain tumour in adults, with glioblastoma multiforme (GBM), the most common and most deadly form of glioma, making up over half of all diagnosed cancers in the brain/central nervous system. The standard of care for gliomas has remained unchanged for...
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Fall 2017
Epidermal Growth Factor-like domain 7 (EGFL7) is a secreted angiogenic factor that is almost exclusively expressed by endothelial cells. High EGFL7 expression occurs during physiological angiogenesis, under pathological conditions, and in solid tumor angiogenesis. Evidence suggests that EGFL7...
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Fall 2022
Heart transplantation (HTx) is a life-saving intervention for patients with end-stage heart failure. Nonetheless, the development of Chronic Allograft Vasculopathy (CAV) limits the longevity of transplanted cardiac allografts and the survival of recipients. The pathogenesis of CAV begins with a...
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Exploiting the Enhanced Permeability and Retention Effect for the Targeting of Tumors with 18F-SiFA Polymer Nanoparticles
DownloadFall 2017
Over the last several decades great progress has been made in cancer diagnosis and detection. One foundation of this progress has been improved imaging technologies. Among the most promising imaging technologies for cancer detection is Positron Emission Tomography (PET). PET imaging allows for...
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Investigating Radiation in Combination with Oncolytic Vaccinia Virus to Improve the Treatment of Glioblastoma
DownloadFall 2023
Glioblastoma (GBM) is a malignant and immune-suppressed brain cancer that remains incurable despite the current standard of care. Radiotherapy is a mainstay of GBM treatment, however invasive cancer cells outside the irradiated field and radioresistance preclude complete eradication of GBM cells....
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Fall 2016
Thrombotic microangiopathy (TMA) is a broad term for a range of diseases that usually manifest with rapid failure of the affected organ. Although different in etiology, these diseases share a common pattern of injury originating in the vascular endothelium. In turn, the injured vasculature...
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Manipulation of the Angiogenic Balance by Pharmacological Inhibition of Platelet PKC Signalling
DownloadFall 2012
Blood platelets mediate wound healing by preventing bleeding and by supporting growth of new blood vessels. Blood vessel growth is supported in part by growth factors released from platelet α-granules. Both platelet aggregation and α-granule release are mediated by intracellular signaling...
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Fall 2013
The placenta is an essential transitory fetal organ responsible for the key processes of nutrient, oxygen, and waste transfer between the mother and the fetus throughout gestation. Placental size is, importantly, known to correlate to fetal weight, and the malfunction and malformation of the...