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Skip to Search Results- 1Afanas'yev, Dmytro
- 1Begam, Rowshon A
- 1Fayadh, Abdullah
- 1Kandel, Krishna
- 1Kumpula, David J
- 1Levesque, Crystal
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Fall 2017
Amino acids are building blocks for protein synthesis and are essential to every metabolic process. A well-balanced diet is one in which all required amino acids are present in the food that is eaten. Unfortunately, this is not always the case and nutritional supplements can be used to make up...
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Amino acid and biogenic amine concentrations during experimental autoimmune encephalomyelitis and the disease-modifying effects of phenelzine treatment
DownloadFall 2011
The project described in this thesis began with a broad analysis of the changes to amino acid and biogenic amine concentrations in the central nervous system (CNS) during experimental autoimmune encephalomyelitis (EAE) in mice, an animal model of Multiple Sclerosis (MS). That study identified...
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Fall 2014
Monoamine oxidase enzymes are largely involved in the catabolism of biogenic amines. Two forms of the enzyme are socumented to exist, monoamine oxidase type A and B. The B form (MAO-B) of the enzyme has been noted to possess a high affinity site for some imidazoline ligands. This site (the I2...
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Conformations of Some Amino Acids in Aqueous Solutions by Vibrational Circular Dichroism Spectroscopy
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Vibrational circular dichroism (VCD) spectroscopy has been utilized to reveal the detailed conformational distributions of the dominant serine species and leucine species in aqueous solutions under three representative pH conditions, together with vibrational absorption (VA) spectroscopy, density...
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Evaluation of the threonine requirement and the bioavailability of threonine in feedstuffs in pregnant sows
DownloadFall 2010
Current recommendations for amino acid intake during pregnancy are for a constant amino acid intake throughout. However, the demand for amino acids changes from maternal tissue growth in early gestation to fetal, conceptus and mammary tissue development in late gestation. The availability of...
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Functional characterization of the L-type Amino acid Transporters (LATs) in Arabidopsis thaliana
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The distribution of amino acids (AAs) in plants is a complex process that involves 67 amino acid transporters (AATs) in Arabidopsis, many of which have yet to be characterized. The L-type Amino acid Transporter (LAT) family, which in Arabidopsis contains five members, remained uncharacterized in...
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Neurochemical and neuroprotective aspects of phenelzine and its active metabolite B-phenylethylidenehydrazine
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Phenelzine (PLZ) is a monoamine oxidase (MAO) inhibitor that also inhibits the activity of GABA-transaminase (GABA-T), causing significant and long-lasting increases in brain GABA levels. Inhibition of MAO prior to PLZ administration has been shown to prevent the GABAergic effects of the drug,...
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Novel properties of the multifaceted drug phenelzine and its metabolite β-phenylethylidenehydrazine
DownloadFall 2015
Phenelzine is a monoamine oxidase (MAO) inhibitor that has been used for the treatment of depression and anxiety disorders since the 1960s. In recent years, there has been renewed interest in this drug following reports of its neuroprotective properties in animal models of cerebral ischemia,...