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- 24Nursing research
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- 3Amyloid precursor protein
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- 28Nursing, Faculty of
- 20Graduate and Postdoctoral Studies (GPS), Faculty of
- 20Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
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A History of the Evolution of Nursing Research in the Faculty of Nursing, University of Alberta from 1980 to 1998
DownloadSpring 2017
The purpose of this study was to trace the historical evolution of nursing research at the Faculty of Nursing, University of Alberta between 1980 and 1998. The questions that guided this study were: What were the trends in nursing research, specifically what type of questions were studied and...
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2013
Greta G. Cummings, Leslie Hayduk, Janet E. Squires, Carole A. Estabrooks, Lisa A. Cranley, Alison M. Hutchinson, Peter G. Norton, Mark Gierl
Background and Purpose. In this paper, we present a protocol for advanced psychometric assessments of surveys based on the Standards for Educational and Psychological Testing. We use the Alberta Context Tool (ACT) as an exemplar survey to which this protocol can be applied. Methods. Data mapping,...
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Spring 2016
There is ample evidence that autophagy is affected in Alzheimer’s disease (AD) but the causes, the nature of the dysfunction and the mechanisms of autophagy impairment are unclear. Autophagy depends on vesicular trafficking and membrane fusion, events that rely on several protein complexes and...
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Fall 2019
Alzheimer’s disease (AD) is characterized by the accumulation of amyloid beta (Aβ) peptide. It has been proposed that AD pathology is transmissible by a “prion-like” mechanism through extracellular vesicles (EVs) that contain Aβ. In this context, EVs describe both microvesicles and exosomes,...
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Cellular level/distribution of γ-secretase subunit nicastrin and its modulator p23 in the brain
DownloadSpring 2010
The processing of amyloid precursor protein (APP) by β- and γ-secretases produces amyloid β (Aβ) peptide, the principal component of the neuritic plaques found in Alzheimer’s disease (AD) pathology. The enzyme γ-secretase is a multimeric protein consisting of presenilins-1/2 (PS1/PS2), nicastrin,...
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2009
Schopflocher, D., Newburn-Cook, C. V., Yu, H., Dundon, B., Drummond, J., Neufeld, S. M.
Background Nausea and vomiting is a problem for children after neurosurgery and those requiring posterior fossa procedures appear to have a high incidence. This clinical observation has not been quantified nor have risk factors unique to this group of children been elucidated. Methods A six year...
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Spring 2013
Alzheimer’s disease (AD) is a complex neurodegenerative disorder believed to be triggered by the accumulation of β-amyloid (Aβ)-related peptides derived from the proteolytic processing of amyloid precursor protein (APP). Research over the last two decades has shown that alterations in the levels...