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Skip to Search Results- 2Veldhoen, Richard
- 1Abdualmjid,Reem J
- 1Abdurrahim, Amna E.
- 1Araya, Luam Ellen
- 1Azad, Abul
- 1Baghdasarian, Argishti
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Docosahexaenoic Acid Induced Apoptosis In H9c2 Cells And Changed Cardiac Function After Ischemia-Reperfusion Injury
DownloadSpring 2013
Cardiovascular disease (CVD) remains one of the leading causes of death worldwide. As such, a vast amount of research has investigated novel therapies for preventing and/or reducing CVD. Much evidence has demonstrated the importance of dietary composition in increasing or lowering risks of CVD....
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Fall 2022
Heart transplantation (HTx) is a life-saving intervention for patients with end-stage heart failure. Nonetheless, the development of Chronic Allograft Vasculopathy (CAV) limits the longevity of transplanted cardiac allografts and the survival of recipients. The pathogenesis of CAV begins with a...
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Epithelial and vascular progenitors in the developing lung: Newer insights and therapeutic implications
DownloadFall 2012
Stanislaus Alphonse, Anthuvan Rajesh
Bronchopulmonary dysplasia (BPD) and congenital diaphragmatic hernia (CDH) are life-threatening lung diseases affecting newborn infants. Both diseases are characterized by impaired lung development and are currently untreatable. Dysregulation in the number or function of lung progenitor cells is...
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Evaluation of Phosphatidylserine-Binding Peptides Radiolabeled with Fluorine 18 for in vivo Imaging of Apoptosis
DownloadSpring 2012
We currently do not have a clinical method to directly assess apoptosis induced by cancer therapies. Phosphatidylserine (PS) is an attractive target for imaging apoptosis since it is on the exterior of the apoptotic cells and PS externalization is an early marker of apoptosis. PS-binding peptides...
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Spring 2016
Flaviviruses, such as West Nile virus (WNV), Powassan virus (POW), and Saint Louis encephalitis virus (SLEV), are significant pathogens capable of causing serious neurological disease in both humans and animals. Despite their relevance to human health, treatment and vaccines for these viruses...
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Fall 2015
During infection, the host cell environment must be altered to accommodate viral replication. These alterations include hijacking cellular membranes as well as other components to form viral replication compartments and attenuating the host defenses to prevent virus detection and elimination....
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From the basic understanding of N-myristoylation during apoptosis to a potential personalized medical treatment of B cell lymphomas
DownloadFall 2013
Myristoylation is a type of fatty acylation that involves the irreversible attachment of myristate (C14) to an amino-terminal glycine of a protein via an amide bond by N-myristoyltransferase (NMT). The two human N-myristoyltransferases (NMT1 and NMT2) typically play a pro-survival role in cells...
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Fall 2012
Approximately 70% of patients infected with hepatitis C virus (HCV) develop chronic infection, which has been reported to be due to impaired specific T cell responses. Myeloid dendritic cells (mDCs) are potent antigen-presenting cells that regulate T cell responses, however their role during...
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Herpes Simplex Virus Requires VP11/12 to Activate Src Family Kinase-PI3 Kinase-Akt Signalling
DownloadFall 2010
This thesis defines a novel role for the Herpes Simplex Virus (HSV) tegument protein, virion protein (VP) 11/12 as a modulator of host cell signalling. Studies aimed at examining infection induced lymphocyte inactivation, revealed that VP11/12 is tyrosine phosphorylated in three lymphocyte...