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Skip to Search Results- 1Elwi, Adam
- 1Heaton, Timothy Peter.
- 1Kantor, Chase M
- 1McKenzie, Sheila Grace.
- 1Omar, Mohamed Abdalla
- 1Panaitescu, Bogdan Alexandru
- 2Ballanyi, Klaus (Physiology)
- 1Ballanyi, Klaus (Physiology Department, University of Alberta)
- 1Cass, Carol (Oncology)
- 1Clanachan, AS (Pharmacology)
- 1Dickson, Clayton (Neuroscience and Mental Health Institute, Psychology, Physiology, Anesthesiology and Pain Medicine
- 1Funk, Gregory D (Physiology, University of Alberta)
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Fall 2022
The reason and functional relevance of why we sleep continues to perplex researchers. One fundamental reason behind why sleep remains a mystery is because it is challenging to study given how easily it is disrupted. Anesthesia has been suggested to be a model for studying sleep given the...
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Antagonistic modulation of spontaneous neural network activities in isolated newborn rat brainstem preparations by opioids and methylxanthines
DownloadFall 2012
Apnea of prematurity is a common problem among the infants born before term pregnancy. Administration of respiratory stimulating drugs methylxanthines is the most frequent therapy, often in combination with the use of intubation. Opioids are used to reduce the pain associated with intubation,...
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Fall 2012
ATP actions on central inspiratory networks are determined by a three-part signaling system comprising: i) excitatory actions of ATP at P2 receptors (Rs) ii) ectonucleotidases that degrade ATP into adenosine (ADO), and iii) inhibitory actions of ADO at P1Rs. During hypoxia, an initial increase in...
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Calcium Imaging and Field Potential Analysis of Autocrine Neuromodulation in the Locus Coeruleus of Newborn Rat Brain Slices
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The locus coeruleus (LC) is a small brainstem nucleus that controls diverse behaviours and brain functions via release of noradrenaline (NA) in the neonatal time period. There is increasing evidence of complexity in this neuron-astrocyte ‘neural’ network that remains mostly unexplored in...
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Spring 2012
Myocardial energy substrate metabolism is subjected to significant changes during ischemia and reperfusion (I/R), which can greatly influence post-ischemic recovery of left-ventricular (LV) mechanical function. One of the main mechanisms that contribute to I/R injury is the accumulation of...
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Modulation of Spontaneous Neural Network Bursting in Newborn Rat Brain Slices by Extracellular Calcium, Methylxanthines, and Opioids
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Spontaneous neuronal bursting appears to be pivotal for brain maturation. This thesis studied such synchronized neural network oscillations in immature newborn rat hippocampus, cortex, and locus coeruleus. For this, horizontal brain slices were generated for (simultaneous) suction electrode...
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Fall 2009
Human cells possess multiple nucleoside transporters (NTs) that belong to either the human equilibrative or concentrative NT (hENT: hENT1/2/3/4; hCNT: CNT1/2/3) families. In the kidney, coupling of apical hCNT3 activities to basolateral hENT1/2 activities is hypothesized to mediate renal...