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Skip to Search Results- 1Abdul Rahman, Siti Aishah
- 1Alles, Sascha R
- 1Chen, Yishen
- 1Conroy, Sherrill A.
- 1Darvesh, Nazia
- 1Dimopoulos, Ioannis
- 6Department of Pharmacology
- 5Centre for Neuroscience
- 4Department of Physiology
- 3Neuroscience
- 1Department of Agricultural, Food, and Nutritional Science
- 1Department of Medicine
- 2Tse, Amy (Centre for Neuroscience and Department of Pharmacology)
- 1Ballanyi, Klaus (Physiology Department, University of Alberta)
- 1Cass, Carol (Oncology)
- 1Chen, Xing-Zhen (Physiology)
- 1Clanachan, AS (Pharmacology)
- 1Clayton T. Dickson (Psychology, Physiology, Anesthesia and Pain Medicine, Neuroscience and Mental Health Institute)
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Spring 2016
This thesis examines the cellular basis of the acute (<1 hour) anti-allodynic actions of the clinically-approved neuropathic pain drug gabapentin (GBP) in rats at the level of the spinal dorsal horn and primary somatosensory cortex. Although the clinical effectiveness of the alpha-2-delta (α2δ)...
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Fall 2022
The reason and functional relevance of why we sleep continues to perplex researchers. One fundamental reason behind why sleep remains a mystery is because it is challenging to study given how easily it is disrupted. Anesthesia has been suggested to be a model for studying sleep given the...
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Adiposity and fat loss in cancer: Exploring the prognostic significance and underlying mechanisms of adipose alterations in cancer
DownloadSpring 2017
During cancer progression, many patients will experience some degree of wasting of both muscle and adipose tissue. However, little is-known about adipose tissue alterations after a cancer diagnosis. Therefore, this research was conducted to first understand the prognostic significance of adipose...
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Antagonistic modulation of spontaneous neural network activities in isolated newborn rat brainstem preparations by opioids and methylxanthines
DownloadFall 2012
Apnea of prematurity is a common problem among the infants born before term pregnancy. Administration of respiratory stimulating drugs methylxanthines is the most frequent therapy, often in combination with the use of intubation. Opioids are used to reduce the pain associated with intubation,...
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Fall 2012
ATP actions on central inspiratory networks are determined by a three-part signaling system comprising: i) excitatory actions of ATP at P2 receptors (Rs) ii) ectonucleotidases that degrade ATP into adenosine (ADO), and iii) inhibitory actions of ADO at P1Rs. During hypoxia, an initial increase in...
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Spring 2012
Myocardial energy substrate metabolism is subjected to significant changes during ischemia and reperfusion (I/R), which can greatly influence post-ischemic recovery of left-ventricular (LV) mechanical function. One of the main mechanisms that contribute to I/R injury is the accumulation of...
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Fall 2014
An individual’s body weight is tightly regulated by balancing food intake with energy expenditure. This is accomplished in part by secretion of the hormone leptin by adipocytes, an excess of which signals to reduce appetite and increase activity through action in the hypothalamic region of the...
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Electrophysiological and Genetic Aspects of Age-Related Macular Degeneration (AMD): Treatment Implications
DownloadFall 2014
Age-related macular degeneration (AMD) is considered a heterogeneous group of disorders. Although many genes influence susceptibility to disease, none has shown to be the primary contributor. To identify genetic contributors, distinct AMD phenotypes need to be established. We relied on...
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Spring 2012
Neuropathic pain afflicts 1.5-3% of the general population. It can be initiated by traumatic nerve injuries or diseases such as diabetic or post-herpetic neuropathy. Neuropathic pain is often initiated by abnormal spontaneous activity in sensory neurons and this provokes increased excitability of...
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2014
Conroy, Sherrill A., Murray, Cynthia L.
Low maternal, gestational weight gain is associated with preterm birth, intrauterine growth restriction, low birthweight, small-for-gestational-age infants, neural tube defects, infant death, failure to initiate breastfeeding, and childhood asthma. The advantage of qualitative research is it can...