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Delineation of molecular mechanisms of intestinal calcium absorption during postnatal development
DownloadFall 2021
Infants and children must maintain a positive calcium balance for appropriate growth. Evidence suggests that adaptations in intestinal absorption of calcium are the major determinant of this net balance. However, the molecular details of the pathways mediating this increased absorption at a young...
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Integrative analysis of the developing diaphragm provides a better understanding of congenital diaphragmatic hernia
DownloadFall 2023
Introduction: Congenital Diaphragmatic Hernia (CDH) is a condition that affects 2.3 births every 10,000 and is characterized by an incomplete formation of the diaphragm. As a result of the incomplete development of the diaphragm, the abdominal organs will protrude into the thoracic cavity,...
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Fall 2023
Infants and children require a net positive calcium (Ca2+) balance to achieve optimal bone mineral density by early adulthood. Vitamin D is a hormone that increases blood Ca2+ levels by increasing intestinal absorption and renal reabsorption of Ca2+ as well as bone remodelling. In both the kidney...
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Fall 2022
Phosphate is important for a variety of physiological functions, including the composition of bone via formation of the calcium-phosphate salt hydroxyapatite. Given that bone mineralization occurs very rapidly early in life, young mammals require high phosphate absorption to establish and...
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Spring 2013
The proximal tubule (PT) is a major site of paracellular transport. Research in this area is undermined by the lack of a model system that is representative of PT electrophysiology. We examined opossum kidney (OK) cell characteristics and found a striking resemblance to the PT (transepithelial...