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Characterization of the Type VI Secretion System in the Bacterial Pathogen Acinetobacter baumannii
DownloadFall 2016
Antibiotic resistant bacteria that cause hospital-acquired infections are a mounting concern for healthcare systems globally. Multidrug resistant (MDR) Acinetobacter baumannii has emerged as a common cause of nosocomial infections, and some isolates are now pandrug resistant. These infections can...
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Exploiting novel Acinetobacter Oligosaccharyltransferases for the development of glycoconjugate vaccines against the Pneumococcus
DownloadSpring 2016
Vaccines bring many diseases under control, an example of which is the Streptococcus pneumoniae, or the Pneumococcus. Pneumococcus is one of the leading causes of meningitis in children under 5 years, and is responsible for almost a million child deaths annually, with more than 90 serotypes...
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Identification and Exploitation of Oligosaccharyltransferase Dependent Bacterial Glycosylation Systems
DownloadFall 2014
Protein glycosylation, the covalent attachment of carbohydrates to amino acids, was once thought to be a unique attribute of Eukaryotes and select bacteria. However, both N- (attached to asparagine) and O- (attached to serine or threonine) glycosylation systems have been identified in an ever...
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Investigating the roles of O-linked Protein Glycosylation and Type Two Secretion in the Pathogenesis of Acinetobacter
DownloadSpring 2017
The Acinetobacter baumannii, A. nosocomialis and A. pittii are Gram-negative opportunistic human pathogens that are of importance to the healthcare system particularily because of their resistance to antibiotics. The thesis below focuses on investigating two virulence attributes of Acinetobacter...
