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Chronic Fatigue Mechanisms in Autoimmune Diseases: Lessons from Primary Biliary Cholangitis and Systemic Sclerosis
DownloadFall 2023
Systemic sclerosis (SSc) is an autoimmune disease affecting the body's connective tissues, resulting in progressive fibrosis and vasculopathy. In some cases, individuals with SSc may also develop primary biliary cholangitis (PBC), another autoimmune disease characterized by damage to their...
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Monitoring Macrophage Immune Gene Expression Profiles as an Early Indicator System for Examining the Bioactivity of Oil Sands Process Affected Waters
DownloadFall 2021
Oil sands process-affected waters (OSPW) are by-products of bitumen (i.e. oil) extraction from the oil sands located in northern Alberta. These large volumes of water are held in tailings ponds and cannot be released due to their potential toxic effects. Overall, tailings ponds and mining...
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Fall 2023
12,13-dihydroxy-9z-octadecenoic acid (12,13-DiHOME) is a linoleic acid-derived cardiac metabolite produced in endotoxin-induced cardiomyopathy, correlating with myocardial dysfunction, inflammation, and mitochondrial damage. The contribution of 12,13-DiHOME to inflammation in the heart is...