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Skip to Search Results- 1Abdul Rahman, Siti Aishah
- 1Abu-Sa'da, Omar SD
- 1Ahrari, Malema
- 1Alles, Sascha R
- 1Chen, Yishen
- 1Cordingley, Dean M.
- 6Department of Pharmacology
- 6Department of Physiology
- 5Centre for Neuroscience
- 3Neuroscience
- 2Faculty of Nursing
- 2Medical Sciences-Medical Genetics
- 2Tse, Amy (Centre for Neuroscience and Department of Pharmacology)
- 1 Thomas Churchill (Department of Surgery)
- 1Al Hamarneh, Yazid (Pharmacology)
- 1Ali, Samina (Pediatrics and Emergency Medicine)
- 1Ballanyi, Klaus (Department of Physiology)
- 1Ballanyi, Klaus (Physiology Department, University of Alberta)
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Electrophysiological and Genetic Aspects of Age-Related Macular Degeneration (AMD): Treatment Implications
DownloadFall 2014
Age-related macular degeneration (AMD) is considered a heterogeneous group of disorders. Although many genes influence susceptibility to disease, none has shown to be the primary contributor. To identify genetic contributors, distinct AMD phenotypes need to be established. We relied on...
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Spring 2012
Neuropathic pain afflicts 1.5-3% of the general population. It can be initiated by traumatic nerve injuries or diseases such as diabetic or post-herpetic neuropathy. Neuropathic pain is often initiated by abnormal spontaneous activity in sensory neurons and this provokes increased excitability of...
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Fall 2015
Polycystic kidney disease (PKD) protein 2 Like 1 (PKD2L1), also called transient receptor potential polycystin-3 (TRPP3), regulates Ca2+-dependent hedgehog signalling in primary cilia, intestinal development and sour tasting but with an unclear mechanism. PKD2L1 is a Ca2+-permeable cation channel...
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Influence of lipids (arachidonic acid and cholesterol) on calcium signalling in rodent pancreatic beta cells
DownloadFall 2010
Ca2+ is an important mediator of stimulus-secretion coupling in beta cells of the pancreatic islets, which secrete insulin in response to elevation in plasma glucose concentration. I studied the actions of two lipids, arachidonic acid (AA) and cholesterol, on enzymatically-dissociated single...
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Fall 2009
The computational ability of principal neurons and interneurons in the brain and their ability to work together in concert are thought to underlie higher order cognitive processes such as learning, memory, and attention. Dendrites play a very important role in neuronal information processing...
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Modulation of Spontaneous Neural Network Bursting in Newborn Rat Brain Slices by Extracellular Calcium, Methylxanthines, and Opioids
DownloadFall 2012
Spontaneous neuronal bursting appears to be pivotal for brain maturation. This thesis studied such synchronized neural network oscillations in immature newborn rat hippocampus, cortex, and locus coeruleus. For this, horizontal brain slices were generated for (simultaneous) suction electrode...
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Nonmedical Use of Opioids Following Short Term Therapeutic Exposure in Children and Youth: A Systematic Review and Qualitative Study of Decision Maker Information Needs
DownloadFall 2021
Introduction Healthcare visits, hospitalizations, and deaths due to opioid-related harms continue to rise for children, despite an overall decline in opioid prescriptions. Decision-makers (including patients, families, clinicians, and policy-makers) require high quality syntheses to inform...
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Pharmacological and Fluorometric Assessment of Neuronal KCNQ Channels, and Implications for Understanding Neurological Disease
DownloadSpring 2020
Epilepsy affects 60 million people worldwide, and encompasses the most common forms of neurological disorders. Epilepsy manifests in diverse ways in patients, ranging from mild cognitive effects, to seizures, to the more severe epileptic encephalopathy. While many pharmacological approaches exist...