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- 1Adenosine. Therapeutic use.
- 1Bicarbonate transporters, carbonic anhydrase
- 1Chloride/bicarbonate exchanger AE1
- 1Coronary heart disease. Animal models.
- 1Glycolysis. Chemotherapy.
- 1Heart. Metabolism.
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Spring 2014
NHE1, whose activity and expression are elevated in cardiac hypertrophy, requires an acidifying pathway provided by AE3-mediated Cl-/HCO3- exchange to sustain its activity. Carbonic anhydrase II (CAII) interacts with NHE1 and AE3 to induce hypertrophy but the role of AE3 in hypertrophy is poorly...
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