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Author: Quach, Kevin Subject: PI3K Languages: English

  • HSV-1 Remodels PI3-Kinase/AKT Signaling

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    Spring 2013

    Quach, Kevin

    AKT inhibits apoptosis and stimulates cap-dependent translation by phosphorylating key downstream cellular proteins. Many viruses therefore activate the PI3-kinase-AKT signaling pathway to promote cell survival and viral protein synthesis. HSV-1 activates AKT during lytic infection and the...

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