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2013

Scott, S. D., Johnson, D. W., Klassen, T. P., Bishop, T., Hartling, L.

Introduction Stories may be an effective tool to communicate with patients because of their ability to engage the reader. Our objective was to evaluate the effectiveness of story booklets compared to standard information sheets for parents of children attending the emergency department (ED) with...

2005

Klassen, T. P., Vandermeer, B., Hartling, L., Robinson, J. L., Crumley, E.

Background: Intravenous gamma globulin (IVGG) is commonly used in the management of acute myocarditis. The objective of this study was to systematically review the literature evaluating this practice. Methods: We conducted a comprehensive search (electronic databases, trials registries,...

2002

Wiebe, N., Klassen, T. P., Hartling, L., Belseck, E. M.

Background Acyclovir has the potential to shorten the course of chickenpox which may result in reduced costs and morbidity. We conducted a systematic review of randomised controlled trials that evaluated acyclovir for the treatment of chickenpox in otherwise healthy children. Methods MEDLINE,...

2005

Klassen, T. P., Lee, D., Tubman, M., Majumdar, S. R., Friesen, C.

Recommendations for improved patients’ safety, specifically the safety of products containing potassium, are often based on practice guidelines and untested recommendations widely endorsed by various experts or organisations Valid and empirical evidence to support or discourage implementation of...

2008

Offringa, M., Hartling, L., Craig, J. C., Klassen, T. P.

Children are often touted as being very important members of society because they represent our future. Optimizing their health outcomes has the potential for a huge impact on public health because children are at an early stage in the life trajectory. But it is often unclear how society...

2005

Swingler, G., Williams, K., Hartling, L., Moyer, V., Cramer, K., Klassen, T. P., Wiebe, N.

Background The delivery of optimal medical care to children is dependent on the availability of child relevant research. Our objectives were to: i) systematically review and describe how children are handled in reviews of drug interventions published in the Cochrane Database of Systematic Reviews...

2010

Tjosvold, L., Thomson, D., Vandermeer, B., Klassen, T. P., Cohen, E., Hartling, L.

Background The objective of this study was to describe randomized controlled trials (RCTs) and controlled clinical trials (CCTs) in child health published between 1948 and 2006, in terms of quantity, methodological quality, and publication and trial characteristics. We used the Trials Register...

2012

Scott, S. D., Hamm, M. P., Hartling, L., Klassen, T. P., Moher, D.

Background Pediatric randomized controlled trials (RCTs) are susceptible to a high risk of bias. We examined the barriers and facilitators that pediatric trialists face in the design and conduct of unbiased trials. Methods We used a mixed methods design, with semi-structured interviews building...

2013

Scott, S. D., Moher, D., Klassen, T. P., Hartling, L., Hamm, M. P.

Introduction A research-practice gap exists between what is known about conducting methodologically rigorous randomized controlled trials (RCTs) and what is done. Evidence consistently shows that pediatric RCTs are susceptible to high risk of bias; therefore novel methods of influencing the...

2006

Vandermeer, B., Hartling, L., Buscemi, N.., Baker, G., Klassen, T. P., Vohra, S., Pandya, R., Tjosvold, L., Hooton, N.

Objective To conduct a systematic review of the efficacy and safety of exogenous melatonin in managing secondary sleep disorders and sleep disorders accompanying sleep restriction, such as jet lag and shiftwork disorder. Data sources 13 electronic databases and reference lists of relevant...