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Skip to Search Results- 3Pediatrics
- 2Biomedical research
- 2Research design
- 1Assessement
- 1Clinical trials as topic
- 1Drug therapy
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2005
Swingler, G., Williams, K., Hartling, L., Moyer, V., Cramer, K., Klassen, T. P., Wiebe, N.
Background The delivery of optimal medical care to children is dependent on the availability of child relevant research. Our objectives were to: i) systematically review and describe how children are handled in reviews of drug interventions published in the Cochrane Database of Systematic Reviews...
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Do health care institutions value research? A mixed methods study of barriers and facilitators to methodological rigor in pediatric randomized trials.
Download2012
Scott, S. D., Hamm, M. P., Hartling, L., Klassen, T. P., Moher, D.
Background Pediatric randomized controlled trials (RCTs) are susceptible to a high risk of bias. We examined the barriers and facilitators that pediatric trialists face in the design and conduct of unbiased trials. Methods We used a mixed methods design, with semi-structured interviews building...
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2013
Scott, S. D., Moher, D., Klassen, T. P., Hartling, L., Hamm, M. P.
Introduction A research-practice gap exists between what is known about conducting methodologically rigorous randomized controlled trials (RCTs) and what is done. Evidence consistently shows that pediatric RCTs are susceptible to high risk of bias; therefore novel methods of influencing the...
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Risk of bias versus quality assessment of randomised controlled trials: cross sectional study.
Download2009
Dryden, D. M., Krebs Seida, J., Ospina, M., Hooton, N., Hartling, L., Klassen, T. P., Liang, Y.
Objectives To evaluate the risk of bias tool, introduced by the Cochrane Collaboration for assessing the internal validity of randomised trials, for inter-rater agreement, concurrent validity compared with the Jadad scale and Schulz approach to allocation concealment, and the relation between...
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Treatment in the pediatric emergency department is evidence based: a retrospective analysis.
Download2006
Wiebe, N., Waters, K. L., Cramer, K., Klassen, T. P., Hartling, L.
Background Our goal was to quantify the evidence that is available to the physicians of a pediatric emergency department (PED) in making treatment decisions. Further, we wished to ascertain what percentage of evidence for treatment provided in the PED comes from pediatric studies. Methods We...