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2012
Thomson, D., Chisholm, A., Hartling, L., Dryden, D. M.
Background: Overviews of systematic reviews compile data from multiple systematic reviews (SRs) and are a new method of evidence synthesis. Objectives: To describe the methodological approaches in overviews of interventions. Design: Descriptive study. Methods: We searched 4 databases from 2000 to...
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Applying the risk of bias tool in a systematic review of combination long-acting beta-agonists and inhaled corticosteroids for persistent asthma.
Download2011
Seida, J., Vandermeer, B., Hartling, L., Dryden, D. M., Rowe, B. H., Bond, K.
Background The Risk of Bias (RoB) tool is used to assess internal validity of randomized controlled trials (RCTs). Our objectives were to: 1) evaluate inter-rater agreement of the RoB tool; 2) determine the time to access supplemental study information; 3) compare the RoB tool with the Jadad...
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From the trenches: a cross-sectional study applying the GRADE tool in systematic reviews of healthcare interventions.
Download2012
Dryden, D. M., Vandermeer, B., Seida, J., Hartling, L., Fernandes, R. M.
Background GRADE was developed to address shortcomings of tools to rate the quality of a body of evidence. While much has been published about GRADE, there are few empirical and systematic evaluations. Objective To assess GRADE for systematic reviews (SRs) in terms of inter-rater agreement and...
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Quantifying bias in randomized controlled trials in child health: a meta-epidemiological study.
Download2014
Hartling, L., Vandermeer, B., Dryden, D. M., Fernandes, R. M., Hamm, M. P.
Objective: To quantify bias related to specific methodological characteristics in child-relevant randomized controlled trials (RCTs). Design: Meta-epidemiological study. Data Sources: We identified systematic reviews containing a meta-analysis with 10–40 RCTs that were relevant to child health in...
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2008
Russell, K., Liang, Y., O'Gorman, K., Klassen, T. P., Friesen, C., Dryden, D. M., Wild, T. C., Durec, T.
Background: Methamphetamine (MA) is a potent stimulant that is readily available. Its effects are similar to cocaine, but the drug has a profile associated with increased acute and chronic toxicities. The objective of this systematic review was to identify and synthesize literature on risk...