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2010
Clawson,M. L., Wang, Z., Stothard, P., McKay, S., Laegreid, W. W., Williams J. L., Murdoch, B. M., Settles, M., Moore, S. S., Prasad, A.
Background Classical bovine spongiform encephalopathy (BSE) is an acquired prion disease that is invariably fatal in cattle and has been implicated as a significant human health risk. Polymorphisms that alter the prion protein of sheep or humans have been associated with variations in...
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A Simple Polymerase Chain Reaction-based Method for the Discrimination of Three Chicken Breeds
Download2009
Mitsuhashi, T., Kubo, Y., Plastow, G.
A large number of branded chicken products exist in Japan, and in some cases, the breed of chicken is an important factor used to attract consumer interest in the retail product. In order to establish a simple method for verifying such breed claims we applied the amplified fragment length...
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A Whole-Genome Scan to Map Quantitative Trait Loci for Conformation and Functional Traits in Canadian Holstein Bulls
Download2008
Grant, J. R., Moore, S. S., Xiu, Z., Murdoch, B. M., Kolbehdari, D., Stothard, P., Wang, Z., Prasad, A., Marques, E.
Genetic improvement of livestock populations can be achieved through detection and mapping of genetic markers linked to quantitative trait loci (QTL). With the completion of the bovine genome sequence assembly, single nucleotide polymorphism (SNP) assays spanning the whole bovine genome and...
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2011
Plastow, G., Durunna, O. N., Stothard, P., Mujibi, F. D. N., Moore, S. S., Wang, Z., Basarab, J. A., Nkrumah, D. J., Crews Jr, D. H., Mah, J.
The benefit of using genomic breeding values (GEBV) in predicting ADG, DMI, and residual feed intake for an admixed population was investigated. Phenotypic data consisting of individual daily feed intake measurements for 721 beef cattle steers tested over 5 yr was available for analysis. The...
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An Assessment of Population Structure in Eight Breeds of Cattle Using a Whole Genome SNP Panel
Download2008
Schnabel, R. D., Wang, Z., Taylor, J. F., Gill, C. A., Van Tassell, C. P., Gao, C., Aerts, J., Williams, J. L., Neto, E. D., Murdoch, B. M., Matukumalli, L. K., Coppieters, W., McKay, S. D., Mannenl, H., Crews, D., Moore, S. S.
Background Analyses of population structure and breed diversity have provided insight into the origin and evolution of cattle. Previously, these studies have used a low density of microsatellite markers, however, with the large number of single nucleotide polymorphism markers that are now...
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Birth Weight, Intrauterine Growth Retardation and Fetal Susceptibility to Porcine Reproductive and Respiratory Syndrome Virus
Download2014
Ashley, C., Foxcroft, G., Plastow, G., Harding, J. C. S., Lunney, J. K., Ladinig, A.
The severity of porcine reproductive and respiratory syndrome was compared in pregnant gilts originating from high and low birth weight litters. One-hundred and eleven pregnant gilts experimentally infected with porcine reproductive and respiratory syndrome virus on gestation day 85 (±1) were...
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Construction of bovine whole-genome radiation hybrid and linkage maps using high-throughput genotyping
Download2007
Williams, J. L., Moore, S. S., Wang, Z., McKay, S. D., Murdoch, B. M.
High-density whole-genome maps are essential for ordering genes or markers and aid in the assembly of genome sequence. To increase the density of markers on the bovine radiation hybrid map, and hence contribute to the assembly of the bovine genome sequence, an Illumina® BeadStation was used to...
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Cytokine profiles in pregnant gilts experimentally infected with porcine reproductive and respiratory syndrome virus and relationships with viral load and fetal outcome
Download2014
Plastow, G., Souza, C. J. H., Lunney, J. K., Ashley, C., Ladinig, A., Harding, J. C. S.
In spite of extensive research, immunologic control mechanisms against Porcine Reproductive and Respiratory Syndrome virus (PRRSv) remain poorly understood. Cytokine responses have been exhaustively studied in nursery pigs and show contradictory results. Since no detailed reports on cytokine...
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Developing a genome-wide selection model for genetic improvement of residual feed intake and carcass merit in a beef cattle breeding program
Download2012
Lai, S., Plastow, G., Zeng, Z., Li, X., Ma, J., Tang, G., Moore, S., Wang, Z.
Residual feed intake (RFI) and carcass merit (CM) are both complex traits emerging as critical targets for beef genetic improvement. RFI and CM traits are difficult and expensive to measure and genetic improvement for these traits through traditional selection methods is not very effective....
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Dominant Red Coat Color in Holstein Cattle Is Associated with a Missense Mutation in the Coatomer Protein Complex, Subunit Alpha (COPA) Gene
Download2015
Sällman Almén, M., Liao, X., Stothard, P., Henegar, C., Van Doormaal, B., Rubin, C. -J., Andersson, L., Barsh, G. S., Ito, S., Plastow, G., Wakamatsu, K., Dorshorst, B.
Coat color in Holstein dairy cattle is primarily controlled by the melanocortin 1 receptor (MC1R) gene, a central determinant of black (eumelanin) vs. red/brown pheomelanin synthesis across animal species. The major MC1R alleles in Holsteins are Dominant Black (MC1RD) and Recessive Red (MC1Re). A...