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A Nutritional Perspective of Ketogenic Diet in Cancer: A Narrative Review
2018-04-01
Oliveira, Camila L. P., Mattingly, Stephanie, Schirrmacher, Ralf, Sawyer, Michael B., Fine, Eugene J., Prado, Carla M.
The predominant use of glucose anaerobically by cancer cells (Warburg effect) may be the most important characteristic the majority of these cells have in common and, therefore, a potential metabolic pathway to be targeted during cancer treatment. Because this effect relates to fuel oxidation,...
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2023-03-01
Ford, Katherine L., Trottier, Claire F., Wismer, Wendy V., Sawyer, Michael B., Siervo, Mario, Deutz, Nicolaas E.P., Prado, Carla M., Vallianatos, Helen
Background Dietary changes often accompany management of a cancer diagnosis, but how and why patients with colorectal cancer (CRC) make dietary decisions requires further investigation. Objective To learn about patients’ food-related beliefs and understand whether and why dietary changes were...
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2012
Ketabi, Ali, Baracos, Vickie E., Field, Catherine J., Lin, Xiaoxi, Xue, Hongyu, Bibova, Ilona, Gänzle, Michael G., Dieleman, Levinus A., Sawyer, Michael B.
Intestinal microbiota mediate toxicity of irinotecan (CPT-11) cancer therapies and cause systemic infection after CPT-11-induced loss of barrier function. The intestinal microbiota and their functions are thus potential targets for treatment to mitigate CPT-11 toxicity. However, microbiota...
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Prophylactic ciprofloxacin treatment prevented high mortality, and modified systemic and intestinal immune function in tumour-bearing rats receiving dose-intensive CPT-11 chemotherapy
Download2009
Baracos, Vickie E., Xue, Hongyu, Sawyer, Michael B., Field, Catherine J
Infectious complications are a major cause of morbidity and mortality from dose-intensive cancer chemotherapy. In spite of the importance of intestinal bacteria translocation in these infections, information about the effect of high-dose chemotherapy on gut mucosal immunity is minimal. We studied...
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Protein Recommendation to Increase Muscle (PRIMe): Study protocol for a randomized controlled pilot trial investigating the feasibility of a high protein diet to halt loss of muscle mass in patients with colorectal cancer
Download2021-02-01
Ford, Katherine L., Sawyer, Michael B., Trottier, Claire F., Ghosh, Sunita, Deutz, Nicolaas E. P., Siervo, Mario, Porter Starr, Kathryn N., Bales, Connie W., Disi, Ilana Roitman, Prado, Carla M.
Background Severe muscle mass (MM) loss is a defining feature of cancer observed across all types and stages of disease and is an independent predictor of poor clinical outcomes including higher incidences of chemotherapy toxicity and decreased survival. Protein is essential to build MM, yet the...
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Single and combined supplementation of glutamine and n-3 polyunsaturated fatty acids on host tolerance and tumour response to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin (CPT-11)/5-fluorouracil chemotherapy in rats bearing Ward colon tumour
Download2009
Xue, Hongyu, Sawyer, Michael B., Le Roy, Severine, Dieleman, Levinus A., Baracos, Vickie E., Field, Catherine J.
Prior reports suggest that during irinotecan (7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin; CPT-11) chemotherapy in laboratory rats, the anti-tumour efficacy and diarrhoea toxicity could be modulated by n-3 PUFA and glutamine, respectively. We further examined how these two...
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Skeletal muscle anabolism is a side effect of therapy with the MEK inhibitor: Selumetinib in patients with cholangiocarcinoma
Download2012
Ghosh, Sunita, Doyle, L. Austin, Baracos, Vickie E., Prado, Carla M., Sawyer, Michael B., Bekaii-Saab, Tanios, Shrestha, Suraj
background: Cancer cachexia is characterised by skeletal muscle wasting; however, potential for muscle anabolism in patients with advanced cancer is unproven. methods: Quantitative analysis of computed tomography images for loss/gain of muscle in cholangiocarcinoma patients receiving selumetinib...
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The role of intestinal microbiota in development of irinotecan toxicity and in toxicity reduction through dietary fibres in rats
Download2014
Baracos, Vickie, Dieleman, Levinus, Farhangfar, Arazm, Lin, Xiaoxi B., Gänzle, Michael G., Sawyer, Michael B., Valcheva, Rosica, Schieber, Andreas
CPT-11 is a drug used as chemotherapy for colorectal cancer. CPT-11 causes toxic side-effects in patients. CPT-11 toxicity has been attributed to the activity of intestinal microbiota, however, intestinal microbiota may also have protective effects in CP!-11 chemotherapy. This study aimed to...
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Total energy expenditure assessed by 24-h whole-room indirect calorimeter in patients with colorectal cancer: baseline findings from the PRIMe study
Download2023-08-01
Ford, Katherine L, Pichard, Claude, Sawyer, Michael B., Trottier, Claire F, Disi, Ilana Roitman, Purcell, Sarah A, Ghosh, Sunita, Siervo, Mario, Deutz, Nicolaas E. P., Prado, Carla M.
Background Total energy expenditure (TEE) determines energy requirements, but objective data in patients with cancer are limited. Objectives We aimed to characterize TEE, investigate its predictors, and compare TEE with cancer-specific predicted energy requirements. Methods This cross-sectional...