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Mechanisms of Prion Disease: Initial Misfolding of the Prion Protein and Metabolomic Changes in the Brain
DownloadFall 2020
Prion diseases are neurodegenerative diseases that are caused by the misfolding and aggregation of cellular prion protein (PrPC) into the pathogenic form termed PrPSc. To contribute to a better understanding of the mechanism of prion disease, in this thesis I present my work on the structural...
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The Prion Protein: Modulation of Potassium Channels and a Novel Mouse Model of a Disease-Causing Hydrophobic Domain Insertion Mutation
DownloadSpring 2016
Mercer, Robert Corrigan Curtis
Prion diseases are invariably fatal neurodegenerative diseases of humans and other mammals. While they can manifest as sporadic, infectious or genetic etiologies, the central event in prion disease is the structural conversion of the prion protein (PrPC) to an alternative conformer PrPSc. PrP is...