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Skip to Search Results- 11West, Frederick (Chemistry)
- 8Lowary, Todd (Chemistry)
- 1Bennet, Andy (SFU Chemistry)
- 1Cambpell, Robert (Chemistry)
- 1Hall, Dennis (Chemistry)
- 1Lucy, Charles (Chemistry)
- 1Ahmed Hamdy Mahmoud Elmenoufy
- 1Akuamoah Boateng, Maxwell
- 1Bonderoff, Sara A
- 1Bott, Tina Marie
- 1Byers, Brock W
- 1Dunbar, Christine R
- 2Interrupted Nazarov reaction
- 2Nazarov reaction
- 11,3-oxathiane
- 1Acetylcholine
- 1Allylic alcohol transposition
- 1Alternative Nazarov reaction
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The construction of diverse nitrogen-containing heterocycles via the reaction of amines of azides with metallocarbenes
DownloadFall 2011
A fundamental goal in organic chemistry is the development of new and innovative ways of transforming simple building blocks into complex structures. The formation of ylides from the reaction of metallocarbenes with heteroatoms, such as the nitrogen of an amine or azide, is an example of a...
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Synthetic Studies Towards (+)-Dactylol Utilizing an Oxonium Ylide Rearrangement and Related Studies.
DownloadFall 2011
Dactylol is a structurally interesting sesquiterpene natural product. One of its key structural features is an the eight-membered ring. The challenges of synthesizing an eight membered ring are discussed in Chapter 1. In addition, various methods for generating an eight-membered ring are...
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Fall 2012
Mammalian glycoconjugates are composed exclusively of sugar in the thermodynamically favorable pyranose ring form; on the other hand, sugars in the five-membered furanose ring form are widespread in many bacteria, fungi, and protozoan pathogens. This makes the enzymes involved in furanoside...
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Fall 2012
5-Membered carbocycles are ubiquitous in natural products and synthetic drugs. Methods of generating them are therefore valuable, and the ability to do so in a stereospecific and enantioselective manner while making considerable gains in molecular complexity with additional incorporation of...
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Fall 2014
Carbohydrate–protein interactions play key roles in a range of biological processes. Noticeable advancements have been made in understanding the features associated with the recognition of pyranosides (six-membered ring sugars) by proteins. In contrast, similar detailed studies about the...
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Spring 2014
Fluorous phase chemistry is an emerging field in terms of new separation techniques. A highly fluorinated compound tends to dissolve in a fluorinated solvent rather than in a common organic solvent. Fluorophilic solid phase separation (F-SPE) techniques are also well established. Our goal is to...
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Synthesis of Furanose Sugar Nucleotides from Mycobacterium tuberculosis and Campylobacter jejuni
DownloadSpring 2014
Five-membered ring furanose sugars, though absent in mammals, have been found in the cell walls of pathogenic bacteria such as Mycobacterium tuberculosis and Campylobacter jejuni. Because these sugars are only found in microorganisms, it has been proposed that inhibiting the enzymes these...
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Fall 2014
This dissertation expands the scope and understanding of the Nazarov electrocyclization and interception of the reactive cyclopentenyl cation intermediate that is formed though a 4π electrocyclization of a pentadienyl cation. An intermolecular process for interrupting the Nazarov is discussed....
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Spring 2015
Diastereomeric piperidinium salts were prepared as substrates for the Stevens [1,2]-rearrangement of ammonium ylides, the key step in a proposed synthetic route towards lysergic acid, a valuable compound in medicinal and synthetic chemistry. Because of unexpected reactivity seen in the alkylation...
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Spring 2015
Five-membered carbocycles are highly prevalent motifs in natural products and pharmaceutical drugs. Finding routes towards these moieties has been an attractive area of pursuit in synthetic organic chemistry. The Nazarov reaction is one that has been widely used to access cyclopentenone...