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Mechanism of Training Induced Functional Gains and CST Sprouting after SCI: The role of PKA Signaling
DownloadFall 2015
Currently the most effective treatment in humans for promoting recovery after spinal cord injury (SCI) is rehabilitative training. However, training is not equally effective for all injury severities and usually does not lead to complete recovery. As a result, there is a need for treatments that...
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MODELING INCOMPLETE CERVICAL SPINAL CORD INJURY IN RATS TO EXPLORE MECHANISMS OF REHABILITATIVE TRAINING
DownloadFall 2013
Although limited functional recovery is observed following spinal cord injury (SCI), the most successful approach to promote recovery to date has been rehabilitative training. However, the effects of training are not stunning. With a thorough understanding of the intracellular mechanisms involved...
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Fall 2013
This thesis explores strategies to promote neuronal plasticity in a rat model of cervical spinal cord injury (SCI) in an effort to achieve improved recovery of skilled forelimb use. I focused on investigating how motor pathways disrupted by an SCI may connect to spared, lesion-bridging relay...