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Fall 2022
Background: Hypertrophic scars (HTS) are a dermal fibroproliferative disorder that commonly occurs following burn injury. Due to the intricate nature of the wound healing process and an incomplete understanding of the molecular mechanisms involved in HTS formation, current treatments have...
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The Effects of Hydraulic Fracturing Flowback and Produced Water on Exercise Capacity and Metabolic Fuel Selection in Rainbow Trout (Oncorhynchus mykiss)
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Hydraulic fracturing is an increasingly popular technique for unconventional hydrocarbon extraction in Canada. As its popularity continues to grow, concerns are being raised regarding its waste product, hydraulic fracturing flowback and produced water (FPW), and its effects on the environment....
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The Development, Feasibility, Acceptability, and Efficacy of a 12-Week Online Mind-Body Intervention for People with Primary Biliary Cholangitis
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Introduction: Persons with primary biliary cholangitis (PBC) experience significantly higher rates of mental distress, impaired health related quality of life (HrQoL), and fatigue than the general population. While mind-body interventions have been shown to improve mental health and HrQoL, and...
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Fall 2022
Zika virus (ZIKV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are important emerging human pathogens that have disrupted global health. More therapeutic and prophylactic treatments for the diseases caused by the emerging viruses are needed. Expansion of our knowledge on the...
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Fall 2022
Affinity maturation is the process to improve antibody affinity for an antigen during an adaptive immune response; it is mediated by the immunoglobulin mutator enzyme activation-induced cytidine deaminase (AID). This process is crucial to produce high-affinity memory B-cells and plasma cells. In...
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Fall 2022
Background: This thesis encompasses two distinct projects. 1) von Willebrand factor (VWF) is a highly adhesive multimeric glycoprotein found in the Weibel-Palade bodies of endothelial cells and in ⍺-granules of megakaryocytes and platelets. At the site of vascular injury, VWF is essential for...
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Fall 2022
Silicon nanoparticles have sparked researchers’ interest as a biologically compatible and abundant quantum dot alternative. Doped silicon nanoparticles (SiNPs) offer unique optical and electronic properties that are not observed for intrinsic Si. These advantageous properties can be applied...
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Fall 2022
Web traffic and e-commerce activities are increasing rapidly; hence, understanding the behavior of users based on their interactions with websites is becoming more and more important. To do so, web usage mining is needed. This research analyzes web clickstream data to extract usage patterns....
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Stimuli-Responsive and Self-Healing Nanocomposite Hydrogels Based on Reversible and Dynamic Crosslinks
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Hydrogels, due to their soft and water abundant natures, highly resemble human skins and tissues and thereby have attracted extensive attention in recent years. Functional hydrogels showing responsiveness to various stimuli such as pH, temperature, strain and pressure are promising for a wide...
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Impact of an employment guarantee program on child health and women's reproductive behaviours in rural India
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In this dissertation, I examine the impact of the world's largest employment guarantee program on child health and women's reproductive behaviours in rural India. The program, popularly known as National Rural Employment Guarantee Scheme (NREGS) was introduced in India in 2005. I utilize two...