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Spring 2015

Zorzela, Liliane Medianeira

Introduction Systematic reviews (SRs) synthesize published and sometimes unpublished data and are often based on randomized controlled trials (RCTs). However, RCTs are known to be poor at identifying and reporting harms. The PRISMA (Preferred Reporting Items for Systematic Reviews and...

Spring 2014

Jaggi, Parneet K

Various clinical questionnaires exist to assist clinicians with the diagnosis, prognosis, long-term follow up of a disease, or even to assess quality of life. However, any questionnaire must be evaluated for its validity and reliability before application. Invalid or unreliable questionnaires can...

Fall 2023

Persad, Kaya L

Proliferating cells, such as neonatal cardiomyocytes, have a high Warburg effect, which is a metabolic state in which there is high rates of glycolysis uncoupled from glucose oxidation under aerobic conditions. The Warburg effect is typically seen in cancerous cells and actively proliferating...

Fall 2021

Pherwani, Simran A

One third of all deaths in Canada are due to cardiovascular diseases, including heart failure. Cardiovascular diseases have a considerable economic burden, and drastically impact the health and quality of life of Canadians. Heart failure (HF) is a clinical condition where the heart is unable to...

Fall 2016

Androschuk, Alaura MA

Fragile X Syndrome (FXS) is neurodevelopmental disorder caused by a trinucleotide CGG repeat expansion that leads to the methylation and transcriptional silencing of the Fragile X mental retardation 1 (fmr1) gene. This results in the loss of Fragile X mental retardation protein (FMRP), an...

Fall 2012

Desai, Prajakta V

Kidney stones and osteoporosis are prevalent clinical conditions posing a large economic burden to the healthcare system. A common risk factor for both these diseases is hypercalciuria, which is the inappropriate excretion of calcium in urine. Changes in serum calcium levels are detected by the...

Fall 2022

Eaton, Andrea

Background. Patient-oriented research promotes the exploration of topics that align with stakeholder- identified, patient-focused priorities. Partnering with caregivers and healthcare professionals to determine their priorities for child and family health research provides direction for future...

Fall 2019

Kebbe, Maryam

Background. Given adolescents’ increasing desire for independence and autonomy, there is a need for research to examine their lived experiences, including concerns, preferences, and priorities. In the context of lifestyle modification for weight management, most adolescents with obesity exhibit...

Fall 2022

Raza, Sarah

Current research efforts are focused on identifying the developmental pathways leading to the emergence of autism spectrum disorder (ASD). Prospective studies of infants at an increased likelihood of ASD report difficulties in emotional regulation (ER) and coordination of social attention (i.e.,...

Spring 2018

Rai, Usha

Background: Balanced development of infant gut microbiota is pivotal for immune maturation and energy homeostasis, and infant gut dysbiosis is associated with increased risk of childhood atopy, allergy and excess weight gain. Shifts in abundance of gut Bacteroidetes and Firmicutes during infancy,...