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High throughput genotyping of single nucleotide polymorphisms in the Plasmodium falciparum dhfr and dhps genes by asymmetric PCR and melt-curve analysis
DownloadFall 2011
Mutations within Plasmodium falciparum dihydrofolate reductase (pfdhfr) and dihydropteroate synthase (pfdhps) genes contribute to resistance to antimalarials such as sulfadoxine-pyrimethamine (SP). Single nucleotide polymorphisms (SNPs) within codons 51, 59, 108 and 164 in the pfdhfr gene and...
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