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- 214Department of Medical Sciences
- 133Department of Oncology
- 12Department of Laboratory Medicine and Pathology
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- 11Department of Medical Genetics
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- 9Gene expression.
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Fall 2018
Colchicine is an anti-mitotic drug that targets unpolymerized tubulin, and inhibits microtubule polymerization. It is primarily used to treat gout but has been investigated in numerous clinical trials to treat conditions such as leukemia (ALL), prostate cancer, and inflammatory diseases. However,...
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Regulation of Anti-tumor Immunity in Colorectal Cancer by Interaction of Exosome Immune Complexes with Fc gamma Receptors
DownloadSpring 2019
Targeted therapy is difficult for colorectal cancer (CRC) due to lack of conserved tumor associated antigens (TAA). Immunotherapies for CRC directed at TAA that can overcome intestinal tolerance need to be developed to improve survival of CRC patients. Exosomes are extracellular vesicles secreted...
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The Role of the Androgen Receptor in Prostate Cancer-induced Platelet Aggregation and Invasion
DownloadFall 2019
Background: Prostate cancer (PCa) is the most common visceral malignancy and third leading cause of cancer death among men in Canada. The 2018 Canadian Cancer Society estimates suggest that 21,300 men were diagnosed and 4,100 patients died of this disease. Metastatic prostate cancer (mPCa) is...
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Spring 2020
To ensure faithful cell division, entry into mitosis must be inhibited in cells with damage or under-replicated DNA. Wee1 and Myt1 are two partially redundant kinases that inhibit mitotic entry through the phosphorylation of the Cdk1/cyclin B complex. Cdk1 is an essential mitotic kinase that...
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4-[18F]Fluoroiodobenzene and its applications in palladium-mediated Sonogashira cross coupling reactions
DownloadFall 2014
Way, Jenilee1; Wang, Monica1; Wuest, Melinda1; Bergmann, Cody1; Hamann, Ingrit1; Wuest, Frank1* 1 University of Alberta, Department of Oncology, Edmonton, Alberta, Canada The ongoing demand for novel 18F-labelled radiotracers is frequently accompanied with the need to develop novel...
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Spring 2015
Ozone (O3) and nitrogen dioxide (NO2) are two criteria pollutants that can result in adverse outcomes that effect both natural environments and human health. As these outcomes have a significant impact on people and their environments, it is necessary to closely monitor the levels of these gases...