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Skip to Search Results- 2Muller, Milan J.
- 2Pippus, Kenneth Gordon, 1955-
- 1Abeywardena, Mahinda Yapa
- 1Abou-Chehade, Kassim D.
- 1Adjei, Alex Asiedu.
- 1Al-Majed, Abdulhakeem A
- 5Rats as laboratory animals.
- 4GABA. Receptors.
- 4Metalloproteinases. Physiological effect.
- 4Pharmacology
- 3Adenosine
- 3Autophagy
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Spring 2024
6-Mercaptopurine (6-MP) maintenance therapy is the mainstay for various types of leukemia and inflammatory bowel disease (IBD). 6-MP is associated with numerous adverse effects including gastrointestinal intolerance, myelotoxicity and hepatotoxicity. This can lead to therapy discontinuation which...
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GABAA Receptors and Tonic Inhibition: Towards an Improved Understanding of Agonist Binding and in vivo Expression of the Extrasynaptic a4b3d Subtype
DownloadFall 2013
The GABAA receptor is the major inhibitory neurotransmitter receptor in the central nervous system. Receptors containing the delta subunit generate tonic inhibition due to their extrasynaptic expression, high affinity for gamma-aminobutyric acid (GABA), and slow densensitization kinetics. The...
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Spring 2016
Heart failure is associated with major changes in cardiac energy metabolism that decrease cardiac efficiency, which can reduce cardiac function. In severe heart failure there is a shift back toward a fetal heart metabolism, with a decrease in mitochondrial oxidative metabolism and increase in...
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Spring 2022
Background: Gut microbiota and diet, specifically fiber rich diets, have been associated with blood pressure regulation and cardiovascular health. Gut microbiota metabolize fiber into short-chain fatty acids (SCFAs) of which, acetate is the most abundant, followed by propionate and butyrate. It...