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Skip to Search Results- 2Muller, Milan J.
- 1Abeywardena, Mahinda Yapa
- 1Abou-Chehade, Kassim D.
- 1Adjei, Alex Asiedu.
- 1Al-Majed, Abdulhakeem A
- 1Ali, Mohammad M. A.
- 5Rats as laboratory animals.
- 4GABA. Receptors.
- 4Metalloproteinases. Physiological effect.
- 4Pharmacology
- 3Adenosine
- 3Autophagy
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Fall 2017
Within diseases such as coronary artery disease (CAD) and peripheral artery disease (PAD) ischemia is induced in tissues due to arterial accumulation of atherosclerotic plaque. A novel therapeutic approach to restore blood flow is to neutralize anti-angiogenic factors that could limit...
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Spring 2021
Slow gating regulation is an extrinsic regulatory mechanism that inhibits the activation of Kv1.2 channels. Physiological factors modulating slow gating regulation are incompletely understood and the interplay between slow gating regulation and Kv1.2 channel pharmacology is unexplored. In chapter...
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Fall 2012
Despite originally being described as a secreted protease, matrix metalloproteinase‐2 (MMP‐2) was recently revealed to have targets within cardiomyocytes. The biological mechanism(s) that describes the intracellular localization of MMP‐2 is unknown and is thus the subject of this thesis....
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Novel Roles of Matrix Metalloproteinase-2 in Mitochondrial and Endoplasmic/Sarcoplasmic Reticulum Dysregulation
DownloadFall 2024
Matrix metalloproteinase-2 (MMP-2) is a ubiquitous multifunctional protease that cleaves both extracellular and intracellular proteins. MMP-2 is synthesized as an inactive zymogen. It is rapidly activated inside the cell in response to oxidative stress during different cardiac pathologies such as...
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Fall 2019
Matrix metalloproteinase-2 (MMP-2) is a zinc-dependent protease that proteolyzes numerous substrates both inside and outside the cell when activated during oxidative stress. However, the full gamut of MMP-2 substrates in myocardial oxidative stress injury is largely unknown. This thesis...
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Fall 2015
Youssef, Nermeen Hosny Ibrahim
Plasma membrane ATP-sensitive potassium (KATP) channels are found in many excitable cell types where they couple cellular metabolism and membrane excitability. . Studies on KATP deficient mice show that parameters of cardiac mechanical function are similar to those of wild-type mice under basal...
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Nuclear matrix metalloproteinase-2 and investigation of its potential targets in myocardial ischemia-reperfusion injury
DownloadSpring 2016
Matrix metalloproteinases (MMPs) are zinc-dependent proteases involved in intra- and extra-cellular matrix remodeling. MMP-2 was the first to be localized to the nucleus; however the biological functions and substrates of nuclear MMP-2 are mostly unknown. We hypothesized that...