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Skip to Search Results- 2Jutras, Jean-David
- 2Yip, Eugene
- 1Abdou, Ismail
- 1Adamia, Sophia
- 1Alaee, Mahsa
- 1Anderson, Danielle L.
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Gamma delta T cell immunotherapy against breast cancer and overcoming mechanisms of immune evasion
DownloadSpring 2021
Gamma delta T cells (Tc) are immunosurveillance cells garnering great interest for their anti-tumoral activity. Target cell recognition is mediated by the T cell antigen receptor (TCR) and/or the natural killer receptor NKG2D, whose ligands are upregulated on cancer cells. Tumor cell lysis is...
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Spring 2017
Hybrid magnetic resonance imaging (MRI) and radiation therapy devices are capable of imaging in real-time to track intrafractional lung tumour motion during radiotherapy. In the real time tumour tracking treatment scheme, MR images are acquired in real time, then the tumour target is localized...
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Homology modeling of Suv39h1 and discovery of its small molecule inhibitors by virtual screening and their in vitro validation
DownloadFall 2013
Epigenetic modifications are carried out by specific enzymes and are reversible making them a viable and attractive target to design inhibitors to reset the epigenetic regulatory machinery of the cell and restore it to its normal state. Suppressor of variegation 3-9 homolog 1 (Suv39h1) is a...
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Identification of small molecule inhibitors of the human DNA repair enzyme polynucleotide kinase/phosphatase
DownloadFall 2011
Human polynucleotide kinase/phosphatase (hPNKP) is a bifunctional DNA repair enzyme that phosphorylates DNA 5’-termini and dephosphorylates DNA 3’-termini. hPNKP has been shown to be involved in both single- and double-strand break repair, and cancer cells depleted of hPNKP show significant...
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Impact of conventional fractionated RT to pelvic lymph nodes and dose-escalated hypofractionated RT to prostate gland using IMRT treatment delivery in high-risk prostate cancer
DownloadFall 2009
Prostate cancer is the most common cancer among Canadian men. The standard treatment in high-risk category is radical radiation, with androgen suppression treatment (AST). Significant disease progression is reported despite this approach. Radiation dose escalation has been shown to improve...
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Investigating Radiation in Combination with Oncolytic Vaccinia Virus to Improve the Treatment of Glioblastoma
DownloadFall 2023
Glioblastoma (GBM) is a malignant and immune-suppressed brain cancer that remains incurable despite the current standard of care. Radiotherapy is a mainstay of GBM treatment, however invasive cancer cells outside the irradiated field and radioresistance preclude complete eradication of GBM cells....
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Investigating the role of coiled-coil domain containing protein 3 (CCDC3), a novel secreted protein, in endothelial inflammation
DownloadFall 2015
Endothelial inflammation is critical in the initiation and progression of atherosclerosis and other cardiovascular diseases (CVDs). Tumor necrosis factor-α (TNF-α) is a pro-inflammatory cytokine that induces endothelial inflammation via activation of nuclear factor κB (NF-κB) signaling....
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Fall 2021
The mitotic checkpoint is a failsafe mechanism for the cell to ensure correct chromosome segregation. The evolutionarily conserved kinetochore RZZ complex is an essential component of the mitotic checkpoint. Spindly interacts with the RZZ complex in a farnesylation dependent manner and acts as a...