Search
Skip to Search Results- 2Jutras, Jean-David
- 2Yip, Eugene
- 1Abdou, Ismail
- 1Adamia, Sophia
- 1Alaee, Mahsa
- 1Anderson, Danielle L.
-
Fall 2017
Kazemi Bajestani, Seyyed Mohammad Reza
Background: Cancer cachexia is referred to as a wasting condition, with skeletal muscle and fat loss. Although heart atrophy is recognized as a notable component of experimental cancer cachexia models, it has not been characterized in human studies. The contribution of cardiac structural and...
-
Characterization of transport of positron emission tomography tracer 3′-deoxy-3′-fluorothymidine by nucleoside transporters
DownloadFall 2012
Positron emission tomography (PET) tracer 3′-fluoro-3′-deoxythymidine (FLT) is used for imaging tumor proliferation. Prior to this work, human equilibrative nucleoside transporter 1 (hENT1) was the only known human nucleoside transporter (hNT) capable of FLT transport. The aim of this research...
-
Chemoselective bioconjugation reactions of tyrosine residues for application in PET radiochemistry
DownloadSpring 2018
Achieving chemoselectivity while maintaining bioorthogonality are among some of the major challenges in bioconjugation chemistry. Bioconjugation chemistry has important applications in PET radiochemistry. While modern bioconjugation techniques rely predominantly on lysine and cysteine residues...
-
Colorectal Cancer Small Extracellular Vesicles Induce Matrix Metalloproteinase Expression, an Invasion-Promoting Phenotype, and CD147-Dependent MAPK/AP-1 Activation in Macrophages
DownloadFall 2020
Exosomes and small microvesicles are types of small extracellular vesicle (sEVs) secreted by cancerous and normal cells. sEVs are filled with cargo from cancer cells that may affect both nearby and distant tissues. sEVs from colorectal cancers that enter blood vessels draining the intestine will...
-
Combination Radiation Therapy and Oncolytic Vaccinia Virus Therapy in Preclinical Models of Glioma
DownloadSpring 2017
Gliomas are the most common primary malignant brain tumour in adults, with glioblastoma multiforme (GBM), the most common and most deadly form of glioma, making up over half of all diagnosed cancers in the brain/central nervous system. The standard of care for gliomas has remained unchanged for...
-
Fall 2012
A radiation detector geared towards megavoltage external beam radiotherapy has been developed using a liquid scintillator and a charge coupled device (CCD). The liquid scintillator used is BetaMax ES (MP Biomedicals, Santa Ana, CA) and the CCD comes from an SPC880NC webcam (Royal Philips...
-
Fall 2018
Colchicine is an anti-mitotic drug that targets unpolymerized tubulin, and inhibits microtubule polymerization. It is primarily used to treat gout but has been investigated in numerous clinical trials to treat conditions such as leukemia (ALL), prostate cancer, and inflammatory diseases. However,...