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Skip to Search Results- 1Adam, Ibrahim S. Y.
- 1Airo, Adriana M
- 1Arendt, Christopher William.
- 1Awadh, Abdullah
- 1Azaizeh, Bara'ah
- 1Bacik, John-Paul
- 8Evans, David (Medical Microbiology and Immunology)
- 6Foley, Edan (Medical Microbiology and Immunology)
- 5Barry, Michele (Medical Microbiology and Immunology)
- 5Ingham, Robert (Medical Microbiology and Immunology)
- 5Ostergaard, Hanne (Medical Microbiology and Immunology)
- 3Baldwin, Troy (Medical Microbiology and Immunology)
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Fall 2009
Cytotoxic T lymphocytes (CTL) are differentiated CD8+ T cells that eliminate virally infected cells and tumor cells. CTL lyse target cells by at least two distinct mechanisms: degranulation of cytolytic molecules and cell surface expression of Fas ligand (FasL), which induces apoptosis of...
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Regulation of FasL expression, and delineation of differentiation states of cytotoxic lymphocytes
DownloadSpring 2015
CD8+ T cells are vital cytotoxic lymphocytes against intracellular pathogens and tumor cells. CD8+ T cells utilize a fast-acting degranulation of granzyme/perforin and slow-acting receptor:ligand, FasL:Fas, pathway of inducing target cell lysis. The importance of degranulation based target cell...
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Regulation of HCV Cell-to-Cell Spread by ADP-ribosylation factor 1-Dependent Regulation of Cytosolic Lipid Droplet Homeostasis
DownloadSpring 2018
Hepatitis C virus (HCV) infects cells via cell-free virions by direct cell-to-cell transmission. Entry of cell-free HCV virions has been fairly well-characterized. Several host factors involved in this process have been identified, including the cell surface receptors, tight junction molecules,...
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Fall 2015
Natural Killer (NK) cells are a major part of the innate immune defence against viral infection and tumours. However, our understanding of how NK cells can be exploited for antiviral and antitumor therapy is still in its infancy. We are interested in the interplay between NK cells and Vaccinia...
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Fall 2017
T cell development is a highly dynamic process driven by interactions between developing hematopoietic progenitor cells and numerous cell types that nurture their development. Ultimately, signals detected by developing progenitors lead to the activation of cellular signaling pathways that...
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Fall 2013
Natural killer (NK) cells are innate immune lymphocytes that provide protection against virus infection and transformation. The cytolytic activity of NK cells is controlled by the signaling of receptors that stimulate or inhibit activation. One such inhibitory receptor expressed on human NK cells...