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Skip to Search Results- 1Adam, Ibrahim S. Y.
- 1Airo, Adriana M
- 1Arendt, Christopher William.
- 1Awadh, Abdullah
- 1Azaizeh, Bara'ah
- 1Bacik, John-Paul
- 8Evans, David (Medical Microbiology and Immunology)
- 6Foley, Edan (Medical Microbiology and Immunology)
- 5Barry, Michele (Medical Microbiology and Immunology)
- 5Ingham, Robert (Medical Microbiology and Immunology)
- 5Ostergaard, Hanne (Medical Microbiology and Immunology)
- 3Baldwin, Troy (Medical Microbiology and Immunology)
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Localization and Trafficking of the Death-Inducing Fas Ligand Protein in Cytotoxic T Lymphocytes
DownloadFall 2014
Cytotoxic T lymphocytes (CTL) can kill tumor cells and cells infected with intracellular pathogens. Their two major killing mechanisms are the degranulation pathway and the Fas-FasL pathway. The degranulation process consists of the release of cytolytic perforin and granzyme molecules that are...
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Fall 2015
Natural killer (NK) cells in the mouse and rat rely on homodimeric Ly49 receptors to detect virally infected or transformed cells. The identification of altered cells requires the engagement of Ly49 receptors with MHC class I molecules. The engagement requires contact at three specific sites...
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Mechanism of beta 2 adrenergic receptor (β2AR) agonist in regulation of inflammation in Parkinson’s disease
DownloadFall 2019
Parkinson’s disease (PD) is a progressive neurodegenerative disorder, characterized by degeneration of dopaminergic neurons (DA-neurons) which are primarily present within a region of the brain called as substantia nigra (SN). Several studies suggest that the etiology of the PD includes...
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Mechanisms underlying lymphopenia-driven autoimmunity in the setting of co-inhibitory molecule deficiency
DownloadFall 2016
T lymphocytes (T cells) are powerful directors and effectors of immunity. The system of pseudo-random rearrangements of the T cell receptor (TCR) loci that underlie their ability to recognize a vast universe of molecular patterns is at once useful and dangerous, because many T cells develop TCR...
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Mechanistic Basis for Enhanced Oncolytic Potency by Mutations in Reovirus Sigma1 and Mu2 proteins
DownloadSpring 2020
Wild-type mammalian orthoreoviruses (reoviruses) are non-pathogenic viruses infecting hosts via the respiratory and enteric tracts. There are four prototype reovirus strains: the Type 1 Lang (T1L), Type 2 Jones (T2J), Type 3 Abney (T3A), Type 3 Daring (T3D) and Type 4 Ndelle (T4N). A...
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Spring 2022
Dendritic cells (DCs) are antigen presenting cells critical for the initiation of the adaptive immune response. As such, DCs continually circulate the body to survey for foreign antigen in the periphery. DCs encounter a milieu of environmental cues within the traversed microenvironment that can...