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Skip to Search Results- 1Adam, Ibrahim S. Y.
- 1Airo, Adriana M
- 1Arendt, Christopher William.
- 1Awadh, Abdullah
- 1Azaizeh, Bara'ah
- 1Bacik, John-Paul
- 8Evans, David (Medical Microbiology and Immunology)
- 6Foley, Edan (Medical Microbiology and Immunology)
- 5Barry, Michele (Medical Microbiology and Immunology)
- 5Ingham, Robert (Medical Microbiology and Immunology)
- 5Ostergaard, Hanne (Medical Microbiology and Immunology)
- 3Baldwin, Troy (Medical Microbiology and Immunology)
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Investigating the role of the D0 domain of KIR3DL1 in ligand interaction and exploring the effect of LILRB1 on KIR3DL1 signaling
DownloadFall 2013
Natural killer (NK) cells are crucial in early defense against viral infections by rapidly terminating infected cells and by secreting cytokines to shape adaptive immune responses. The activity of NK cells is regulated by balance of activating and inhibitory signals during interaction with target...
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Investigation of an enhancer-based regulation of LILRB1 gene and the differential functions of LILRB1 variants in natural killer cells
DownloadFall 2020
Human cytomegalovirus (HCMV) causes severe disease in immunocompromised people such as transplant patients. NK cells are crucial in controlling HCMV whereas HCMV developed multiple strategies to evade NK cell surveillance. HCMV encodes a human MHC-I homolog called UL18 to target an inhibitory...
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Investigation of antibody-mediated immune mechanisms during submicroscopic infections of pregnancy-associated malaria in pregnant women from Colombia
DownloadFall 2021
Malaria has been a threat to humans for centuries and continues to be a global health problem. Repeated exposure to malaria in childhood can result in protective immunity that reduces parasite invasion of red blood cells and the sequestration of infected red blood cells (iRBC) in the tissues....
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Spring 2012
Apoptosis, an evolutionarily conserved cell death programme, is a potent barrier against virus infection. Central to this process are mitochondria, which harbour cytochrome c and other apoptosis-inducing factors. Once released, these factors activate a caspase cascade that culminates in cell...
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Investigation of the Molecular Mechanisms That Determine Isolate-Specific, Antibody-Mediated Neutralization of HCV infectivity
DownloadFall 2018
It is estimated that there are about 1.75 million new Hepatitis C Virus (HCV) infections per year worldwide and around 20% will develop liver cirrhosis or liver cancer if left untreated. Direct acting antiviral drugs are available for the treatment of HCV with success rates of over 90%. But...
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Investigations into Differences between Vaccinia and Myxoma Virus Plaquing Properties Identifies Strategies for Increasing the Oncolytic Efficacy of Myxoma Virus
DownloadFall 2013
Despite both being poxviruses, vaccinia (VACV) and myxoma (MYXV) form very different plaque types. VACV plaques are large and show a central clearing of cells, while MYXV plaques are smaller and result in a clumping of cells. VACV spread is promoted by the formation of an enveloped form of virus...
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Spring 2016
Poxviruses, such as vaccinia virus (VACV) and myxoma virus (MYXV), actively modulate various cellular structures and functions to ensure effective replication and transmission. In the contrary, cells use several restriction mechanisms to mitigate these viruses. This evolutionary relationship is...